Dynamic Remodeling of Pericytes In Vivo Maintains Capillary Coverage in the Adult Mouse Brain.
Dynamic Remodeling of Pericytes In Vivo Maintains Capillary Coverage in the Adult Mouse Brain.
复制标题
体内周细胞的动态重塑可在成年小鼠脑中保持毛细管覆盖率。
DOI：
10.1016/j.celrep.2017.12.016
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发表时间：
2018-01-02
期刊：
影响因子：
8.8
通讯作者：
Shih AY
中科院分区：
文献类型：
--
作者：
Berthiaume AA;Grant RI;McDowell KP;Underly RG;Hartmann DA;Levy M;Bhat NR;Shih AY
周细胞和内皮细胞之间的直接接触和通讯对于维持脑血管稳定性和血脑屏障功能至关重要。毛细血管周细胞具有沿着毛细血管床达到数百微米的薄突。相邻周细胞的突起非常接近但不重叠，从而产生具有由各个周细胞占据的离散区域的细胞链。关于这条周细胞链在成人大脑中是否在结构上是动态的，我们知之甚少。在成年小鼠皮层中使用体内双光子成像，我们发现虽然周细胞体体是不动的，但其突起的尖端在几天内经历了延伸和/或缩回。单个周细胞的选择性消融引发了从邻近周细胞到接触内皮未覆盖区域的过程的旺盛延伸。未覆盖的毛细血管区域具有正常的屏障功能，但会扩张直至恢复周细胞接触。周细胞结构可塑性可能对脑血管健康至关重要，值得详细研究。
Direct contact and communication between pericytes and endothelial cells is critical for maintenance of cerebrovascular stability and blood-brain barrier function. Capillary pericytes have thin processes that reach hundreds of micrometers along the capillary bed. The processes of adjacent pericytes come in close proximity but do not overlap, yielding a cellular chain with discrete territories occupied by individual pericytes. Little is known about whether this pericyte chain is structurally dynamic in the adult brain. Using in vivo two-photon imaging in adult mouse cortex, we show that while pericyte somata were immobile, the tips of their processes underwent extensions and/or retractions over days. The selective ablation of single pericytes provoked exuberant extension of processes from neighboring pericytes to contact uncovered regions of the endothelium. Uncovered capillary regions had normal barrier function, but were dilated until pericyte contact was regained. Pericyte structural plasticity may be critical for cerebrovascular health and warrants detailed investigation.
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影响因子：
1.5
作者：
Cuttler, Anne S.;LeClair, Renee J.;Stohn, J. Patrizia;Wang, Qiaozeng;Sorenson, Christine M.;Liaw, Lucy;Lindner, Volkhard
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Zlokovic BV
影响因子：
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作者：
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Kleinfeld, David
缺乏周细胞会导致内皮增生和异常血管形态发生。
影响因子：
7.8
作者：
Hellstrom, M;Gerhardt, H;Kalen, M;Li, X;Eriksson, U;Wolburg, H;Betsholtz, C
通讯作者：
Betsholtz, C