Photoresponsive hydrogel networks using melanin nanoparticle photothermal sensitizers.
Photoresponsive hydrogel networks using melanin nanoparticle photothermal sensitizers.
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DOI：
10.1039/c3bm60321k
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发表时间：
2014-04-01
影响因子：
6.6
通讯作者：
Bettinger CJ
中科院分区：
文献类型：
--
作者：
Ninh C;Cramer M;Bettinger CJ
光可重构和光可降解聚合物网络作为功能生物材料在医学和生物技术中具有广泛的应用。这些功能性聚合物中的绝大多数是使用可能在体外具有细胞毒性的化学部分合成的。由这些取代基合成的材料在植入时也会带来未知的风险，因此在体内使用之前会遇到重大的监管挑战。这项工作描述了一种制备光降解水凝胶网络的策略，该网络由在人体内发现的具有良好特征的合成聚合物和天然黑色素组成。聚（L-丙交酯-共-乙交酯）-聚（乙二醇）阿坝三嵌段共聚物的自组装网络与黑色素纳米粒子掺杂，以产生基于光热相变的可重构网络。具有黑色素纳米颗粒的自组装水凝胶网络表现出范围为1.5 ± 0.6kPa至8.0kPa ± 7.5的储能模量，如通过流变学测量的。紫外线诱导的光热加热的速率是非单调的，并且作为黑色素纳米颗粒负载的函数而变化。测得的最大稳态温升为20.5 ± 0.30 °C。实验加热速率与基于黑色素中的光通过光热吸收和米氏散射的衰减的预测密切一致。还通过流变学和动态光散射表征了黑色素纳米颗粒对水凝胶网络形成和光诱导崩解的影响。总之，这类光可重构水凝胶代表了光可降解聚合物的潜在策略，其临床转化的可能性增加。
Photoreconfigurable and photodegradable polymeric networks have broad utility as functional biomaterials for many applications in medicine and biotechnology. The vast majority of these functional polymers are synthesized using chemical moieties that may be cytotoxic in vitro. Materials synthesized from these substituents also pose unknown risk upon implantation and thus will encounter significant regulatory challenges prior to use in vivo. This work describes a strategy to prepare photodegradable hydrogel networks that are composed of well-characterized synthetic polymers and natural melanin pigments found within the human body. Self-assembled networks of poly(L-lactide-co-glycolide)-poly(ethylene glycol) ABA triblock copolymers are doped with melanin nanoparticles to produce reconfigurable networks based on photothermal phase transitions. Self-assembled hydrogel networks with melanin nanoparticles exhibit a storage modulus ranging from 1.5 ± 0.6 kPa to 8.0 kPa ± 7.5 as measured by rheology. The rate of UV-induced photothermal heating was non-monotonic and varied as a function of melanin nanoparticle loading. A maximum steady state temperature increase of 20.5 ± 0.30 °C was measured. Experimental heating rates were in close agreement with predictions based on attenuation of light in melanins via photothermal absorption and Mie scattering. The implications of melanin nanoparticles on hydrogel network formation and light-induced disintegration were also characterized by rheology and dynamic light scattering. Taken together, this class of photoreconfigurable hydrogels represents a potential strategy for photodegradable polymers with increased likelihood for clinical translation.
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影响因子：
5.5
作者：
Jeong, B;Bae, YH;Kim, SW
通讯作者：
Kim, SW
影响因子：
14.8
作者：
通讯作者：
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疏水性聚合物薄膜上沉积的自聚合多巴胺涂层的表面特性
影响因子：
3.9
作者：
Jiang, Jinhong;Zhu, Liping;Xu, Youyi
通讯作者：
Xu, Youyi
影响因子：
15
作者：
FELIX, CC;HYDE, JS;SEALY, RC
通讯作者：
SEALY, RC
影响因子：
1.1
作者：
Khlebtsov, B. N.;Khlebtsov, N. G.
通讯作者：
Khlebtsov, N. G.