Daily Lifestyle and Inflammatory Skin Diseases.
Daily Lifestyle and Inflammatory Skin Diseases.
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DOI：
10.3390/ijms22105204
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发表时间：
2021-05-14
影响因子：
5.6
通讯作者：
Nakamura M
中科院分区：
文献类型：
--
作者：
Sawada Y;Saito-Sasaki N;Mashima E;Nakamura M
人的一生，都必须适应地球环境才能生存。一个典型的例子是，地球的日常周期与人类的昼夜节律不同；然而，适应地球周期的能力却促进了人类进化的发展。此外，人类可以消费和消化来自地球的食物，并使用奢侈材料来获取营养和丰富自己的生活，以适应地球环境。近年研究表明，日常生活习惯与人体健康密切相关；然而，由于能量摄入过多、吸烟和饮酒导致的肥胖会导致炎症性皮肤病的发生，这一事实却很少受到关注。麸质或小麦蛋白、吸烟和饮酒、睡眠障碍和肥胖会驱动辅助性 T (Th)1/Th2/Th17 免疫反应，而膳食纤维和 omega-3 脂肪酸则负向调节炎症细胞因子的产生。在这篇综述中，我们重点关注日常生活方式和炎症性皮肤病发病机制。
Throughout life, it is necessary to adapt to the Earth’s environment in order to survive. A typical example of this is that the daily Earth cycle is different from the circadian rhythm in human beings; however, the ability to adapt to the Earth cycle has contributed to the development of human evolution. In addition, humans can consume and digest Earth-derived foods and use luxury materials for nutrition and enrichment of their lives, as an adaptation to the Earth’s environment. Recent studies have shown that daily lifestyles are closely related to human health; however, less attention has been paid to the fact that obesity due to excessive energy intake, smoking, and alcohol consumption contributes to the development of inflammatory skin diseases. Gluten or wheat protein, smoking and alcohol, sleep disturbance, and obesity drive the helper T (Th)1/Th2/Th17 immune response, whereas dietary fiber and omega-3 fatty acids negatively regulate inflammatory cytokine production. In this review, we have focused on daily lifestyles and the mechanisms involved in the pathogenesis of inflammatory skin diseases.
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影响因子：
13.8
作者：
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通讯作者：
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作者：
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