Novel transposable elements from Anopheles gambiae.
Novel transposable elements from Anopheles gambiae.
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DOI：
10.1186/1471-2164-12-260
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发表时间：
2011-05-23
期刊：
影响因子：
4.4
通讯作者：
Ribeiro JM
中科院分区：
文献类型：
--
作者：
Fernández-Medina RD;Struchiner CJ;Ribeiro JM
转座因子（Transposable elements，TE）是存在于大多数真核生物基因组中的DNA序列，其具有能够在染色体内移动和增加其拷贝数的关键特征。这些元件对于真核基因组结构和进化是重要的，并且最近被认为是将转基因引入病原体传播昆虫作为控制媒介传播疾病的手段的潜在驱动因素。这项工作的目的是使用PILER工具对冈比亚按蚊基因组内的TE的多样性和丰度进行编目，并以超链接电子表格的形式合并数据库，该数据库包含有关冈比亚按蚊基因组中存在的TE的详细且易于获得的信息。冈比亚。在这里，我们提出了一个名为AnoTExcel的电子表格，它构成了一个数据库，其中包含蚊子基因组中存在的大多数重复元件的详细信息。尽管以前的工作在这个主题上，我们的方法允许识别和表征先前描述的和新的TE，进一步详细描述。鉴定和表征给定基因组中的TE是重要的，作为了解给定物种中存在的整个TE集合的多样性和进化的一种方式。这项工作有助于更好地了解蚊子基因组中存在的TE的景观。它还提出了一个新的平台，用于鉴定，分析和表征测序基因组上的TE。
Transposable elements (TEs) are DNA sequences, present in the genome of most eukaryotic organisms that hold the key characteristic of being able to mobilize and increase their copy number within chromosomes. These elements are important for eukaryotic genome structure and evolution and lately have been considered as potential drivers for introducing transgenes into pathogen-transmitting insects as a means to control vector-borne diseases. The aim of this work was to catalog the diversity and abundance of TEs within the Anopheles gambiae genome using the PILER tool and to consolidate a database in the form of a hyperlinked spreadsheet containing detailed and readily available information about the TEs present in the genome of An. gambiae. Here we present the spreadsheet named AnoTExcel that constitutes a database with detailed information on most of the repetitive elements present in the genome of the mosquito. Despite previous work on this topic, our approach permitted the identification and characterization both of previously described and novel TEs that are further described in detailed. Identification and characterization of TEs in a given genome is important as a way to understand the diversity and evolution of the whole set of TEs present in a given species. This work contributes to a better understanding of the landscape of TEs present in the mosquito genome. It also presents a novel platform for the identification, analysis, and characterization of TEs on sequenced genomes.
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