Gamma delta T cell reconstitution is associated with fewer infections and improved event-free survival after hematopoietic stem cell transplantation for pediatric leukemia.
Gamma delta T cell reconstitution is associated with fewer infections and improved event-free survival after hematopoietic stem cell transplantation for pediatric leukemia.
复制标题
DOI：
10.1016/j.bbmt.2014.09.027
复制
发表时间：
2015-01
影响因子：
4.3
通讯作者：
Dallas, Mari H.
中科院分区：
文献类型：
--
作者：
Perko, Ross;Kang, Guolian;Sunkara, Anusha;Leung, Wing;Thomas, Paul G.;Dallas, Mari H.
在造血干细胞移植(HSCT)后，成功的植入和免疫恢复是防止患者复发和感染的必要条件。许多研究强调了造血干细胞移植后常规αβT细胞恢复的重要性，但γδT细胞恢复的影响尚未得到很好的描述。在这里，我们调查了1996年至2011年在圣裘德儿童研究医院接受异基因造血干细胞移植的102例首次临床缓解的急性白血病儿童患者的γδT细胞恢复情况。患者平均年龄10.5±5.9岁(0.6~25.2岁)，存活患者平均随访2.7±1.8年(0.12~6.0岁)。诊断包括59%的ALL患者和41%的AML患者。多因素分析显示CD3+、CD4+和CD8+T细胞的最大数量和供者来源对γδT细胞回收率有显著影响(P<；0.0001、P<；0.0001、P<；0.0001和P<；0.004)。单因素和多因素模型显示移植后γδT细胞数量与感染有关(P=0.026.0 5和P=0.0 2)。我们发现，γδT细胞数量升高的患者与γδT细胞数量低或正常的患者相比，移植后感染的可能性显著降低(18%比54%；P=0.025)。在γδT细胞升高的患者中未观察到细菌感染。最后，在造血干细胞移植后，增强γδT细胞重建的患者的无事件存活率显著高于低/正常γδT细胞重建的患者(91%比55%；P=0.04)。因此，γδT细胞在造血干细胞移植后的免疫重建中可能起重要作用。
After hematopoietic stem cell transplantation (HSCT), successful engraftment and immune recovery is necessary to protect the patient from relapse and infection. Many studies highlight the importance of conventional αβ T cell recovery after HSCT but the impact of γδ T cell recovery has not been well described. Here, we investigate the recovery of γδ T cells in 102 pediatric patients with acute leukemia in first clinical remission that underwent an allogeneic HSCT at St. Jude Children’s Research Hospital from 1996-2011. The mean age of the patients was 10.5 ± 5.9 years (range, 0.6-25.2) and the mean follow up of the survivors was 2.7±1.8 years (range 0.12-6.0). Diagnoses included 59% patients with ALL and 41% patients with AML. Multivariate analysis demonstrated significant impact of the maximum number of CD3+, CD4+ and CD8+ T cells and donor source on the γδ T cell recovery (P<0.0001, P<0.0001, P<0.0001 and P <0.004; respectively). Univariate and multivariate model found the number of γδ T cells after HSCT to be associated with infections (P = 0.026 and P = 0.02, respectively). We found the probability of infections for patients with an elevated number of γδ T cells was significantly lower compared to patients with low or normal γδ T cells after HSCT (18% vs. 54%; P=0.025). Bacterial infections were not observed in patients with elevated γδ T cells. Lastly, event free survival was significantly higher in patients with enhanced γδ T cell reconstitution compared to patients with low/normal γδ T cell reconstitution after HSCT (91% vs. 55%; P=0.04). Thus, γδ T cell may play an important role in immune reconstitution after HSCT.
登录
查看更多内容
影响因子：
3.6
作者：
GRAY, BM;EGAN, ML;PRITCHARD, DG
通讯作者：
PRITCHARD, DG
影响因子：
1.9
作者：
PRENTICE, RL;KALBFLEISCH, JD;BRESLOW, NE
通讯作者：
BRESLOW, NE
DOI：
10.1073/pnas.250470797
发表时间：
2000-12-05
影响因子：
11.1
作者：
Fukui, Y;Oono, T;Sasazuki, T
通讯作者：
Sasazuki, T
影响因子：
6.5
作者：
Burjanadze, Maka;Condomines, Maud;Lu, Zhao Yang
通讯作者：
Lu, Zhao Yang
影响因子：
5.4
作者：
PFEFFER, K;SCHOEL, B;WAGNER, H
通讯作者：
WAGNER, H