A closer look at astrocyte morphology: Development, heterogeneity, and plasticity at astrocyte leaflets.
A closer look at astrocyte morphology: Development, heterogeneity, and plasticity at astrocyte leaflets.
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DOI：
10.1016/j.conb.2022.102550
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发表时间：
2022-06
影响因子：
5.7
通讯作者：
中科院分区：
文献类型：
--
作者：
星形胶质细胞是一种丰富的神经胶质细胞，几乎参与中枢神经系统（CNS）功能的各个方面，包括突触形成和成熟、离子和神经递质稳态、血脑屏障维持以及神经元代谢支持。这些不同的功能是由星形胶质细胞采用的形态复杂性实现的。最新的实验进展，遗传和病毒标记，谱系追踪，和生活和超微结构成像的微小的星形胶质细胞亚隔室揭示了一个复杂的形态异质性，是基于星形胶质细胞的起源，局部功能和环境背景。在这篇简短的综述中，我们强调了最近的发现，揭示了健康大脑中星形胶质细胞的可塑性，特别是在突触处，以及新兴技术，这些技术促进了我们对这些形态复杂细胞的理解。
Astrocytes represent an abundant type of glial cell involved in nearly every aspect of central nervous system (CNS) function, including synapse formation and maturation, ion and neurotransmitter homeostasis, blood-brain barrier maintenance, as well as neuronal metabolic support. These various functions are enabled by the morphological complexity that astrocytes adopt. Recent experimental advances in genetic and viral labeling, lineage tracing, and live- and ultrastructural imaging of miniscule astrocytic sub-compartments reveal a complex morphological heterogeneity that is based on the origin, local function, and environmental context in which astrocytes reside. In this minireview, we highlight recent findings that reveal the plastic nature of astrocytes in the healthy brain, particularly at the synapse, and emerging technologies that have advanced our understanding of these morphologically complex cells.
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影响因子：
16.6
作者：
Lanjakornsiripan D;Pior BJ;Kawaguchi D;Furutachi S;Tahara T;Katsuyama Y;Suzuki Y;Fukazawa Y;Gotoh Y
通讯作者：
Gotoh Y
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Muller, Dominique
影响因子：
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通讯作者：
Tranque, Pedro