Pubertal exposure to bisphenol A affects the reproduction of male mice and sex ratio of offspring
Pubertal exposure to bisphenol A affects the reproduction of male mice and sex ratio of offspring
复制标题
青春期接触双酚A影响雄性小鼠的繁殖和后代性别比
DOI：
10.7669/j.issn.1001-7844.2015.01.0014
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发表时间：
2015-03
期刊：
影响因子：
--
通讯作者：
Runsheng LI
中科院分区：
文献类型：
--
作者：
Xiao-yu ZHOU;Hong-jie PAN;Yang LI;Runsheng LI
目的研究青春期暴露双酚A（BPA）对成年雄性小鼠及子代生殖的影响。方法21 d龄雄性小鼠腹腔注射BPA，剂量为50 mg/kg·d，连续7 d。染毒35 d后，检测精子计数、精子畸形率和睾丸组织学变化。通过与正常雌性小鼠交配，进一步观察雄性小鼠的生育指数和新生儿。结果BPA染毒组大鼠附睾精子数较对照组减少20.6%（P<0.01）; BPA组精子畸形率比对照组高9.65%（P<0.05）。睾丸曲细精管异常，生殖细胞脱落; BPA暴露对成年雄性小鼠生育力无明显影响;子代雌雄比增加。结论青春期暴露BPA可使成年小鼠精子发生障碍，雄性后代比例增加。
Objective To study the effects of pubertal exposure to bisphenol A (BPA) on the reproduction of male mice in adulthood and subsequent generation mice. Methods Male mice aged 21 d were exposed to BPA at a dose of 50 mg/kg per day for 7 d by intraperitoneal injection. Sperm count, sperm deformity rate and testis histology were evaluated 35 d after exposure. Male fertility index and newborns were further observed by mating with the normal female mice. Results The epididymal sperm number was decreased by 20.6% in BPA exposure group compared with the control (P<0.01). Sperm deformity rate in BPA group was increased by 9.65% compared with the control (P<0.05). Testis seminiferous tubules were abnormal with sloughing of germ cells; BPA exposure had no significant effects on the fertility of male mice in adulthood; sex ratio of male to female offspring was increased. Conclusion Pubertal exposure to BPA disrupted spermatogenesis in adult mice, and the proportion of male offspring was increased compared with the control.
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DOI：
10.1016/b978-141603848-1.10019-1
发表时间：
2019-12
期刊：
Journal of Andrology and Gynaecology
影响因子：
--
作者：
G. Egloff;I. Bender;Jasmin;Roemer
通讯作者：
G. Egloff;I. Bender;Jasmin;Roemer
影响因子：
10.4
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DOI：
10.1073/pnas.1107958108
发表时间：
2011-07-12
影响因子：
11.1
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通讯作者：
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影响因子：
2
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影响因子：
4.1
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Izumi, Nanae;Yanagibori, Ryoko;Sajiki, Junko
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