The Protective Effect of Naringenin on Airway Remodeling after Mycoplasma Pneumoniae Infection by Inhibiting Autophagy-Mediated Lung Inflammation and Fibrosis.
The Protective Effect of Naringenin on Airway Remodeling after Mycoplasma Pneumoniae Infection by Inhibiting Autophagy-Mediated Lung Inflammation and Fibrosis.
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柚皮素通过抑制自噬介导的肺部炎症和纤维化对肺炎支原体感染后气道重塑的保护作用
DOI：
10.1155/2018/8753894
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发表时间：
2018
影响因子：
4.6
通讯作者：
Jiang Z
中科院分区：
文献类型：
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作者：
Lin Y;Tan D;Kan Q;Xiao Z;Jiang Z
本课题组前期研究表明，中药清肺通络方对肺炎支原体肺炎（MP）有显著的治疗作用。本研究的目的是探讨QTF的重要成分--柚皮素（NRG）对MPP的治疗作用及其机制。在这里，我们研究了124名儿童与MPP和比较炎症细胞因子和纤维蛋白原相关蛋白的表达与酶联免疫吸附试验。我们还采用了BALB/c小鼠MPP模型，并将小鼠分为三组：正常对照小鼠（caclide）、MPP（MP感染小鼠）和MPP + NRG（用NRG治疗MP感染小鼠）。BEAS-2B细胞用于确认自噬、炎症和纤维化之间的关系。结果表明，MP感染后，促炎细胞因子（IL-6、IL-1β、肿瘤坏死因子-α）和转化生长因子β（TGF-β）的表达均显著增加。体内实验证实，NRG治疗通过抑制自噬介导的炎性细胞因子表达和肺纤维化减少MPP诱导的小鼠肺损伤。这些结果表明，NRG治疗通过抑制MP感染后的自噬来抑制炎症反应和肺纤维化。
Our previous study has shown that Chinese medicine, Qingfei Tongluo formula (QTF), has a significantly therapeutic effect to Mycoplasma pneumoniae (MP) pneumonia (MPP). The aim of this study was to investigate the therapeutic effect and mechanism of naringenin (NRG) on MPP which was an important component of QTF. Here, we studied 124 children with or without MPP and compared inflammatory cytokines and fibrinogen-related protein expression with enzyme-linked immunosorbent assay. We also employed a BALB/c mouse model of MPP and divided the mice into three groups: ctrl (normal control mice), MPP (MP-infected mice), and MPP + NRG (MP-infected mice treated with NRG). BEAS-2B cells were used to confirm the relationship between autophagy, inflammation, and fibrosis. The results show proinflammatory cytokines (interleukin- [IL-] 6, IL-1β, and tumor necrosis factor-α), and transforming growth factor beta (TGF-β) expression was significantly increased after MP infection from both clinical and animal experiment. In vivo experimental confirmation showed that NRG treatment decreased MPP-induced lung injury in mice by inhibiting autophagy-mediated inflammatory cytokine expression and pulmonary fibrosis. In vitro experiments confirmed it. These results indicate that NRG treatment suppressed the inflammatory response and pulmonary fibrosis by inhibition of autophagy after MP infection.
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右美托咪定通过上调 HIF-1α 抑制神经元自噬保护小鼠脑免受缺血再灌注损伤
影响因子：
5.3
作者：
Luo C;Ouyang MW;Fang YY;Li SJ;Zhou Q;Fan J;Qin ZS;Tao T
通讯作者：
Tao T
影响因子：
2.8
作者：
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Sultana, S.
影响因子：
4.3
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Hernández-Aquino E;Zarco N;Casas-Grajales S;Ramos-Tovar E;Flores-Beltrán RE;Arauz J;Shibayama M;Favari L;Tsutsumi V;Segovia J;Muriel P
通讯作者：
Muriel P
DOI：
10.3412/jsb.70.369
发表时间：
2015-01-01
期刊：
Nihon saikingaku zasshi. Japanese journal of bacteriology
影响因子：
--
作者：
Shimizu, Takashi
通讯作者：
Shimizu, Takashi
影响因子：
30.5
作者：
通讯作者：
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