The prevalence and outcomes of depression in older HIV-positive adults in Northern Tanzania: a longitudinal study.
The prevalence and outcomes of depression in older HIV-positive adults in Northern Tanzania: a longitudinal study.
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DOI：
10.1007/s13365-023-01140-4
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发表时间：
2023-08
影响因子：
3.2
通讯作者：
Paddick, Stella Maria
中科院分区：
文献类型：
--
作者：
Dua, Damneek;Stubbs, Oliver;Urasa, Sarah;Rogathe, Jane;Duijinmaijer, Ashanti;Howlett, William;Dekker, Marieke;Kisoli, Aloyce;Mukaetova-Ladinska, Elizabeta B.;Gray, William K.;Lewis, Thomas;Walker, Richard W.;Dotchin, Catherine L.;Lwezuala, Bingileki;Makupa, Philip C.;Paddick, Stella Maria
目前，撒哈拉以南非洲缺乏对老年艾滋病毒感染者（PLWH）抑郁症及其后果的研究。本研究旨在调查坦桑尼亚年龄≥ 50岁的PLWH中精神疾病的患病率，重点关注抑郁症的患病率和2年结局。从门诊系统招募年龄≥ 50岁的PLWH，并使用迷你国际神经精神访谈（MINI）进行评估。在第2年随访时评估神经和功能损害。基线时，招募了253名PLWH（72.3%为女性，中位年龄57岁，95.5%接受cART治疗）。DSM-IV抑郁症非常普遍（20.9%），而其他DSM-IV精神疾病并不常见。在随访时（n = 162），DSM-IV抑郁症的发生率从14.2%下降到11.1%（χ2：2.48，p = 0.29）;这种下降并不显著。基线抑郁与功能和神经功能损害增加相关。随访时，抑郁症与负性生活事件（p = 0.001）、神经功能缺损（p < 0.001）和功能缺损增加（p = 0.018）相关，但与HIV和社会人口学因素无关。在这种情况下，抑郁症似乎非常普遍，并与较差的神经和功能结果以及负面生活事件相关。抑郁症可能是未来的干预目标。在线版本包含补充材料，可通过10.1007/s13365-023-01140-4获得。
Studies of depression and its outcomes in older people living with HIV (PLWH) are currently lacking in sub-Saharan Africa. This study aims to investigate the prevalence of psychiatric disorders in PLWH aged ≥ 50 years in Tanzania focussing on prevalence and 2-year outcomes of depression. PLWH aged ≥ 50 were systematically recruited from an outpatient clinic and assessed using the Mini-International Neuropsychiatric Interview (MINI). Neurological and functional impairment was assessed at year 2 follow-up. At baseline, 253 PLWH were recruited (72.3% female, median age 57, 95.5% on cART). DSM-IV depression was highly prevalent (20.9%), whereas other DSM-IV psychiatric disorders were uncommon. At follow-up (n = 162), incident cases of DSM-IV depression decreased from14.2 to 11.1% (χ2: 2.48, p = 0.29); this decline was not significant. Baseline depression was associated with increased functional and neurological impairment. At follow-up, depression was associated with negative life events (p = 0.001), neurological impairment (p < 0.001), and increased functional impairment (p = 0.018), but not with HIV and sociodemographic factors. In this setting, depression appears highly prevalent and associated with poorer neurological and functional outcomes and negative life events. Depression may be a future intervention target. The online version contains supplementary material available at 10.1007/s13365-023-01140-4.
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影响因子：
6.8
作者：
Bell JA;Kivimäki M;Bullmore ET;Steptoe A;MRC ImmunoPsychiatry Consortium;Carvalho LA
通讯作者：
Carvalho LA
影响因子：
1.7
作者：
Grov C;Golub SA;Parsons JT;Brennan M;Karpiak SE
通讯作者：
Karpiak SE
DOI：
10.4068/cmj.2015.51.1.8
发表时间：
2015-04
期刊：
Chonnam medical journal
影响因子：
--
作者：
Kang HJ;Kim SY;Bae KY;Kim SW;Shin IS;Yoon JS;Kim JM
通讯作者：
Kim JM
DOI：
10.7860/jcdr/2014/7725.4927
发表时间：
2014-10-01
期刊：
Journal of clinical and diagnostic research : JCDR
影响因子：
--
作者：
Bhatia, M S;Munjal, Sahil
通讯作者：
Munjal, Sahil
影响因子：
3.7
作者：
Bernard C;Dabis F;de Rekeneire N
通讯作者：
de Rekeneire N