Prevalence and factors associated with depression in people living with HIV in sub-Saharan Africa: A systematic review and meta-analysis.

Prevalence and factors associated with depression in people living with HIV in sub-Saharan Africa: A systematic review and meta-analysis.
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DOI:
10.1371/journal.pone.0181960
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发表时间:
2017
期刊:
影响因子:
3.7
通讯作者:
de Rekeneire N
de Rekeneire N
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Bernard C;Dabis F;de Rekeneire N

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抑郁症是最常见的精神疾病之一,在许多情况下,艾滋病毒感染者(PLHIV)的患病率是普通人群的两到三倍,如西方国家所示,但在撒哈拉以南非洲(SSA)仍然被忽视。我们的目的是总结现有的证据,抑郁症的患病率和相关因素,根据所使用的量表和治疗状态在SSA的艾滋病毒感染者。在接受抗逆转录病毒治疗(ART)和未治疗或混合(治疗/未治疗)的艾滋病毒感染者中,抑郁症的合并患病率估计值介于9%和32%之间,根据所使用的测量量表以及给定的量表,差异很大。艾滋病毒感染者接受抗逆转录病毒治疗的社会经济条件差、女性和混合/未经治疗的艾滋病毒感染者的免疫抑制常被报告为相关因素,但尚未达成共识。由于抑郁症可能对艾滋病毒感染者的生活产生有害影响,因此鼓励其筛查和管理,将这些方面纳入整个SSA的艾滋病毒护理中至关重要。
Depression, one of the most common psychiatric disorders, is two- to three-times more prevalent in people living with HIV (PLHIV) than in the general population in many settings as shown in western countries but remains neglected in sub-Saharan Africa (SSA). We aimed to summarize the available evidence on the prevalence of depression and associated factors according to the scales used and the treatment status in PLHIV in SSA. The pooled prevalence estimates of depression ranged between 9% and 32% in PLHIV on antiretroviral treatment (ART) and in untreated or mixed (treated/untreated) ones, with a substantial variability according to the measurement scale used and also for a given scale. Low socio-economic conditions in PLHIV on ART, female sex and immunosuppression in mixed/untreated PLHIV were frequently reported as associated factors but with no consensus. As depression could have deleterious consequences on the PLHIV life, it is critical to encourage its screening and management, integrating these dimensions in HIV care throughout SSA.
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