Parallel Evolution of Serotonergic Neuromodulation Underlies Independent Evolution of Rhythmic Motor Behavior
Parallel Evolution of Serotonergic Neuromodulation Underlies Independent Evolution of Rhythmic Motor Behavior
复制标题
5-羟色胺神经调节的平行进化是节律运动行为独立进化的基础
作者：
Joshua L. Lillvis;P. Katz
神经调节可以动态地改变神经元和突触的特性，从而改变神经回路的行为输出。因此可以想象，自然选择可能作为一种机制作用于神经调节，以塑造一个物种的行为曲目。在这里，我们报告了神经调节的存在与一种行为的产生有关，这种行为最有可能在两个物种中独立进化：Tritonia diomedea和Pleurobranchaea california（软体动物、腹足动物、蛇鳃动物、裸胸膜动物）。这两个物种的个体都表现出逃避游泳的行为，包括反复的背-腹全身弯曲。这些行为背后的中枢模式发生器（CPG）回路包含同源的已鉴定神经元：海鼠的DSI和C2以及胸膜鳃的As和A1。这些神经元的同源物也可以在Hermissenda crassicornis中发现，它们分别被命名为CPT和C2。然而，这个物种的成员并没有表现出类似的游泳行为。在Tritonia和pleurobranchae中，5 -羟色胺能DSI同源物调节C2同源物形成的突触强度，但在Hermissenda中没有。此外，5 -羟色胺受体拮抗剂甲基塞吉特阻断了这种神经调节和游泳行为。此外，在胸膜鳃动物中，游泳的稳健性与突触调节的程度相关。注射5 -羟色胺可诱导海棠和胸膜鳃类动物的游泳行为，但对海棠没有影响。这表明，类似的游泳行为的Tritonia和胸膜鳃有一个共同的依赖血清素能神经调节。因此，神经调节可能提供了一种机制，使物种能够使用同源的神经回路组件独立地获得类似的行为。
Neuromodulation can dynamically alter neuronal and synaptic properties, thereby changing the behavioral output of a neural circuit. It is therefore conceivable that natural selection might act upon neuromodulation as a mechanism for sculpting the behavioral repertoire of a species. Here we report that the presence of neuromodulation is correlated with the production of a behavior that most likely evolved independently in two species: Tritonia diomedea and Pleurobranchaea californica (Mollusca, Gastropoda, Opisthobranchia, Nudipleura). Individuals of both species exhibit escape swimming behaviors consisting of repeated dorsal-ventral whole-body flexions. The central pattern generator (CPG) circuits underlying these behaviors contain homologous identified neurons: DSI and C2 in Tritonia and As and A1 in Pleurobranchaea. Homologs of these neurons also can be found in Hermissenda crassicornis where they are named CPT and C2, respectively. However, members of this species do not exhibit an analogous swimming behavior. In Tritonia and Pleurobranchaea, but not in Hermissenda, the serotonergic DSI homologs modulated the strength of synapses made by C2 homologs. Furthermore, the serotonin receptor antagonist methysergide blocked this neuromodulation and the swimming behavior. Additionally, in Pleurobranchaea, the robustness of swimming correlated with the extent of the synaptic modulation. Finally, injection of serotonin induced the swimming behavior in Tritonia and Pleurobranchaea, but not in Hermissenda. This suggests that the analogous swimming behaviors of Tritonia and Pleurobranchaea share a common dependence on serotonergic neuromodulation. Thus, neuromodulation may provide a mechanism that enables species to acquire analogous behaviors independently using homologous neural circuit components.
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影响因子：
2.5
作者：
Jing, J;Gillette, R
通讯作者：
Gillette, R
影响因子：
2.5
作者：
Clemens, S;Katz, PS
通讯作者：
Katz, PS
影响因子：
2.5
作者：
Jing, J;Gillette, R
通讯作者：
Gillette, R
翼足类软体动物 Clione limacina 游泳速度的血清素调节。
DOI：
10.1242/jeb.198.4.917
发表时间：
1995
期刊：
The Journal of experimental biology
影响因子：
--
作者：
Satterlie,RA;Norekian,TP
通讯作者：
Norekian,TP
Hermissenda 中的血清素免疫反应性 CPT 中间神经元：感觉输入和运动投射的识别。
影响因子：
2.5
作者：
Tian,Lian-Ming;Kawai,Ryo;Crow,Terry
通讯作者：
Crow,Terry