Geometrical confinement of gadolinium-based contrast agents in nanoporous particles enhances T1 contrast.
Geometrical confinement of gadolinium-based contrast agents in nanoporous particles enhances T1 contrast.
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DOI：
10.1038/nnano.2010.203
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发表时间：
2010-11
影响因子：
38.3
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中科院分区：
文献类型：
--
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磁共振成像造影剂目前通过改变其结构和物理化学性质来设计，以改善弛豫性并增强图像对比度。在这里，我们展示了一种通过将造影剂限制在硅颗粒的纳米多孔结构内来增加弛豫率的一般方法。将Magevist、钆富勒烯和钆纳米管装载在准半球形和盘状颗粒的孔内。对于纳米构建体的所有组合，观察到纵向质子弛豫率r1的提高：对于Magevist，r1~14 mM-1 s-1/Gd 3+离子（~8.15×10+7 mM-1 s-1/构建体）;对于钆富勒烯，r1~200 mM-1 s-1/Gd 3+离子（~7×10+9 mM-1 s-1/构建体）;对于钆纳米管，r1~150 mM-1 s-1/Gd 3+离子（~2×10+9 mM-1 s-1/构建体）。这些弛豫率值比临床上可用的钆基试剂（~4 mM-1 s-1 /Gd 3+离子）大约4至50倍。对比度的增强归因于试剂的几何限制，其影响Gd 3+离子的顺磁行为。因此，纳米级限制提供了一种新的和一般的策略，用于增强钆基造影剂的对比度。
Magnetic resonance imaging contrast agents are currently designed by modifying their structural and physiochemical properties in order to improve relaxivity and to enhance image contrast. Here we show a general method for increasing relaxivity by confining contrast agents inside the nanoporous structure of silicon particles. Magnevist, gadofullerenes and gadonanotubes were loaded inside the pores of quasi-hemispherical and discoidal particles. For all combinations of nanoconstructs, a boost in longitudinal proton relaxivity r1 was observed: for Magnevist, r1~14 mM-1s-1/Gd3+ion (~8.15×10+7 mM-1s-1/construct); for gadofullerenes, r1~200 mM-1s-1/Gd3+ion (~7×10+9 mM-1s-1/construct); for gadonanotubes, r1~150 mM-1s-1/Gd3+ion (~2×10+9 mM-1s-1/construct). These relaxivity values are about 4 to 50 times larger than that of clinically-available gadolinium-based agents (~4 mM-1s-1 /Gd3+ion). The enhancement in contrast is attributed to the geometrical confinement of the agents, which influences the paramagnetic behavior of the Gd3+ions. Thus, nanoscale confinement offers a new and general strategy for enhancing the contrast of gadolinium-based contrast agents.
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影响因子：
18.3
作者：
Mulder, Willem J. M.;Strijkers, Gustav J.;Van Tilborg, Geralda A. F.;Cormode, David P.;Fayad, Zahi A.;Nicolay, Klaas
通讯作者：
Nicolay, Klaas
影响因子：
4
作者：
Lebduskova, Petra;Sour, Angelique;Merbach, Andre E.
通讯作者：
Merbach, Andre E.
影响因子：
4.9
作者：
Sitharaman, B;Kissell, KR;Wilson, LJ
通讯作者：
Wilson, LJ
影响因子：
10.8
作者：
Richard, Cyrille;Doan, Bich-Thuy;Scherman, Daniel
通讯作者：
Scherman, Daniel
影响因子：
15
作者：
Laus, S;Sitharaman, B;Merbach, AE
通讯作者：
Merbach, AE