Latent representations in hippocampal network model co-evolve with behavioral exploration of task structure.
Latent representations in hippocampal network model co-evolve with behavioral exploration of task structure.
复制标题
海马网络模型中的潜在表示与任务结构的行为探索共同发展。
DOI:
10.1038/s41467-024-44871-6
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发表时间:
2024-01-23
影响因子:
16.6
通讯作者:
Clopath, Claudia
中科院分区:
文献类型:
--
作者:
Cone, Ian;Clopath, Claudia
To successfully learn real-life behavioral tasks, animals must pair actions or decisions to the task’s complex structure, which can depend on abstract combinations of sensory stimuli and internal logic. The hippocampus is known to develop representations of this complex structure, forming a so-called “cognitive map”. However, the precise biophysical mechanisms driving the emergence of task-relevant maps at the population level remain unclear. We propose a model in which plateau-based learning at the single cell level, combined with reinforcement learning in an agent, leads to latent representational structures codependently evolving with behavior in a task-specific manner. In agreement with recent experimental data, we show that the model successfully develops latent structures essential for task-solving (cue-dependent “splitters”) while excluding irrelevant ones. Finally, our model makes testable predictions concerning the co-dependent interactions between split representations and split behavioral policy during their evolution. How mechanisms of single-cell plasticity lead to task-dependent cognitive maps remains unclear. Here, the authors show that this model of hippocampus shows that cooperation between local plasticity and reinforcement learning of behavior can lead to task-specific latent representations.
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影响因子:
7.7
作者:
Milstein AD;Li Y;Bittner KC;Grienberger C;Soltesz I;Magee JC;Romani S
通讯作者:
Romani S
DOI:
10.1126/science.abm1670
发表时间:
2022-03-18
期刊:
Science (New York, N.Y.)
影响因子:
--
作者:
通讯作者:
--
影响因子:
64.8
作者:
通讯作者:
--
影响因子:
64.8
作者:
Losonczy, Attila;Makara, Judit K.;Magee, Jeffrey C.
通讯作者:
Magee, Jeffrey C.
影响因子:
5.3
作者:
OKEEFE, J
通讯作者:
OKEEFE, J