Segmentation of carotid plaque using multicontrast 3D gradient echo MRI.
Segmentation of carotid plaque using multicontrast 3D gradient echo MRI.
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DOI：
10.1002/jmri.22886
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发表时间：
2012-04
影响因子：
4.4
通讯作者：
Kerwin, William S.
中科院分区：
文献类型：
--
作者：
Liu, Wenbo;Balu, Niranjan;Sun, Jie;Zhao, Xihai;Chen, Huijun;Yuan, Chun;Zhao, Huilin;Xu, Jianrong;Wang, Guangzhi;Kerwin, William S.
目的：评价单独使用多对比3D梯度回波（GRE） MR成像自动分割动脉粥样硬化斑块成分的性能。共有15例近期有短暂性脑缺血发作或中风病史的患者接受了双侧颈动脉血管壁成像，结合二维涡轮自旋回波（TSE）序列和三维梯度回波（GRE）序列。TSE序列包括t1加权、t2加权和对比增强t1加权扫描。3D GRE序列包括飞行时间（TOF）、磁化制备快速梯度回波（MP-RAGE）和运动敏感驱动平衡制备快速梯度回波（MERGE）扫描。根据这些图像，先前开发的形态学增强概率斑块分割（MEPPS）算法仅基于3D GRE序列进行重新训练，以分割坏死核心（NC），钙化（CA）和松散矩阵（LM）。通过将新的3D-MEPPS算法与基于传统多重对比度协议（包括2D TSE和TOF序列）的原始MEPPS算法进行比较，使用留一交叉验证方法评估分割性能。在所有成像序列的覆盖范围内，发现15名受试者的20条动脉表现出明显的斑块。对于这些动脉，在新的和原始的MEPPS算法之间，NC、CA和LM的每片面积的相关系数分别为0.86、0.99和0.80；未观察到明显的区域偏倚。三维成像序列（TOF， MP-RAGE和MERGE）的组合可以提供足够的对比度来区分NC， CA和LM。使用三维序列的自动分割与传统的多对比度协议产生了高度相似的结果。
To evaluate the performance of automatic segmentation of atherosclerotic plaque components using solely multi-contrast 3D gradient echo (GRE) MR imaging. A total of 15 patients with a history of recent transient ischemic attacks or stroke underwent carotid vessel wall imaging bilaterally with a combination of 2D turbo spin echo (TSE) sequences and 3D gradient echo (GRE) sequences. The TSE sequences included T1-weighted, T2-weighted, and contrast-enhanced T1-weighted scans. The 3D GRE sequences included time-of-flight (TOF), magnetization-prepared rapid gradient echo (MP-RAGE), and motion-sensitized driven equilibrium prepared rapid gradient echo (MERGE) scans. From these images, the previously developed morphology-enhanced probabilistic plaque segmentation (MEPPS) algorithm was retrained based solely on the 3D GRE sequences to segment necrotic core (NC), calcification (CA) and loose matrix (LM). Segmentation performance was assessed using a leave-one-out cross-validation approach via comparing the new 3D-MEPPS algorithm to the original MEPPS algorithm that was based on the traditional multi-contrast protocol including 2D TSE and TOF sequences. Twenty arteries of 15 subjects were found to exhibit significant plaques within the coverage of all imaging sequences. For these arteries, between new and original MEPPS algorithms, the areas per slice exhibited correlation coefficients of 0.86 for NC, 0.99 for CA and 0.80 for LM; no significant area bias was observed. The combination of 3D imaging sequences (TOF, MP-RAGE and MERGE) can provide sufficient contrast to distinguish NC, CA and LM. Automatic segmentation using 3D sequences and traditional multi-contrast protocol produced highly similar results.
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影响因子：
4.8
作者：
Underhill, Hunter R.;Yuan, Chun;Hatsukami, Thomas S.
通讯作者：
Hatsukami, Thomas S.
影响因子：
8.3
作者：
Takaya, N;Yuan, C;Hatsukami, TS
通讯作者：
Hatsukami, TS
DOI：
10.1161/01.atv.19.11.2756
发表时间：
1999-11-01
影响因子：
8.7
作者：
Shinnar, M;Fallon, JT;Fuster, V
通讯作者：
Fuster, V
影响因子：
4.4
作者：
Crowe, LA;Keegan, J;Firmin, DN
通讯作者：
Firmin, DN
影响因子：
3.3
作者：
Hofman, JMA;Branderhorst, WJ;Romeny, BMT
通讯作者：
Romeny, BMT