Validation of blood phosphatidylethanol as an alcohol consumption biomarker in patients with chronic liver disease.
Validation of blood phosphatidylethanol as an alcohol consumption biomarker in patients with chronic liver disease.
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DOI：
10.1111/acer.12442
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发表时间：
2014-06
期刊：
影响因子：
--
通讯作者：
Reuben A
中科院分区：
文献类型：
--
作者：
Stewart SH;Koch DG;Willner IR;Anton RF;Reuben A
血磷脂酰乙醇（PEth）是一种有前途的生物标志物的酒精消费。本研究旨在评估其在肝病患者中的性能。这项研究包括222名肝病患者。获得患者报告的酒精使用作为参考标准，并通过串联质谱法测量PEth。使用受试者工作特征（ROC）和列联表分析评估PEth在检测过去30天内每天饮酒和平均饮酒4次或以上的性能。在定量限（20 ng/mL）下，对于过去一个月内的任何饮酒，PEth的敏感性为73%（95%置信区间（CI）65-80），特异性为96%（95% CI 92-100）。饮酒但PEth结果为阴性的受试者主要是轻度饮酒者。报告戒酒30天但有可量化PEth的受试者要么报告在过去6周内大量饮酒，要么有数据表明饮酒不足。在80 ng/mL的最佳临界浓度下，对于平均每天至少4次饮酒，PEth的敏感性为91%（95% CI 82-100），特异性为77%（95% CI 70-83）。PEth是检测肝病患者酒精使用的有用测试，但大量饮酒的截止浓度将导致一些中度至重度饮酒者的错误分类。
Blood phosphatidylethanol (PEth) is a promising biomarker of alcohol consumption. This study was conducted to evaluate its performance in patients with liver disease. This study included 222 patients with liver disease. Patient-reported alcohol use was obtained as a reference standard, and PEth was measured by tandem mass spectrometry. Receiver operating characteristic (ROC) and contingency table analyses were used to assess the performance of PEth in detecting any drinking and averaging 4 or more drinks daily in the past 30 days. At the limit of quantitation (20 ng/mL), PEth was 73% sensitive (95% confidence interval (CI) 65–80) and 96% specific (95% CI 92–100) for any drinking in the past month. Subjects who drank but had a negative PEth result were mainly light drinkers. Subjects who reported 30-day abstinence but with quantifiable PEth either reported heavy drinking within the past 6 weeks or had data that suggested under-reported drinking. At the optimal cutoff concentration of 80 ng/mL, PEth was 91% sensitive (95% CI 82–100) and 77% specific (95% CI 70–83) for averaging at least 4 drinks daily. PEth is a useful test for detecting alcohol use in liver disease patients, but cutoff concentrations for heavy drinking will result in misclassification of some moderate to heavy drinkers.
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DOI：
10.1097/01.alc.0000156082.08248.ab
发表时间：
2005-03-01
影响因子：
3.2
作者：
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通讯作者：
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影响因子：
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DOI：
10.1111/j.1530-0277.2009.01113.x
发表时间：
2010-03-01
期刊：
Alcoholism, clinical and experimental research
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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