Antigen recognition. V. Requirement for histocompatibility between antigen-presenting cell and B cell in the response to a thymus-dependent antigen, and lack of allogeneic restriction between T and B cells.
Antigen recognition. V. Requirement for histocompatibility between antigen-presenting cell and B cell in the response to a thymus-dependent antigen, and lack of allogeneic restriction between T and B cells.
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DOI：
10.1084/jem.154.3.676
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发表时间：
1981-09-01
期刊：
影响因子：
--
通讯作者：
Diener E
中科院分区：
文献类型：
--
作者：
Nisbet-Brown E;Singh B;Diener E
通过体内过继转移系统研究了主要组织相容性复合体对T-B-抗原呈递细胞（APC）相互作用的限制，使用从单向胎肝嵌合体中获得的相互耐受的T和B细胞。发现B细胞和过继受体（其提供APC功能）必须共享由H-2复合物的左手端编码的决定子以进行合作，而对于T-B细胞同源性显然没有这种要求。通过使用耐受和正常的过继受体，排除了宿主和转移的T或B细胞之间的同种异体效应引起的抑制;两者在功能上是等同的。我们的结论是，在实验条件下，不受限制的辅助T细胞功能和并发APC-B细胞的遗传限制，可以在体内证明。
The restrictions imposed by the major histocompatibility complex on T-B- antigen-presenting cell (APC) interactions were studied with an in vivo adoptive transfer system, using mutually tolerant T and B cells taken from one-way fetal liver chimeras. It was found that the B cells and adoptive recipient (which provides APC function) have to share determinants encoded by the left-hand end of the H-2 complex for cooperation, whereas there is apparently no such requirement for T-B cell syngeneicity. Suppression arising from allogeneic effects between the host and the transferred T or B cells was excluded by the use of tolerant as well as normal adoptive recipients; both were functionally equivalent. We conclude that under experimental conditions, unrestricted helper T cell function and concurrent APC-B cell genetic restriction can be demonstrated in vivo.
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影响因子：
15.3
作者：
BOSWELL, HS;NERENBERG, MI;SINGER, A
通讯作者：
SINGER, A
影响因子：
15.3
作者：
KATZ, DH;HAMAOKA, T;BENACERRAF, B
通讯作者：
BENACERRAF, B
影响因子：
15.3
作者：
MATZINGER, P;MIRKWOOD, G
通讯作者：
MIRKWOOD, G
影响因子：
15.3
作者：
SHIH, WWH;MATZINGER, PC;DUTTON, RW
通讯作者：
DUTTON, RW
影响因子：
15.3
作者：
SPRENT, J
通讯作者：
SPRENT, J