Expression of myc, fos and Ha‐ras associated with chemically induced cell proliferation in the rat liver
Expression of myc, fos and Ha‐ras associated with chemically induced cell proliferation in the rat liver
复制标题
大鼠肝脏中 myc、fos 和 Ha-ras 的表达与化学诱导的细胞增殖相关
DOI：
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发表时间：
1994
影响因子：
8.5
通讯作者：
B. E. Butterworth
中科院分区：
文献类型：
--
作者：
T. Goldsworthy;S. Goldsworthy;C. Sprankle;B. E. Butterworth
Abstract. Events secondary to induced cell proliferation may play a role in the carcinogenic process. These studies investigated the expression of genes associated with growth control in response to two types of cell proliferation stimuli in the livers of male F344 rats. Regenerative hepatocyte proliferation after partial hepatectomy or a single dose of carbon tetrachloride, and mitogenic liver hyperplasia induced by a single dose of pheno‐barbital or WY‐14,643 were assessed by thymidine incorporation and quantitative autoradiography. The expression of myc, fos, and Ha‐ras was evaluated by Northern blot analysis of liver derived poly(A)+ mRNA from these same animals. After each treatment, the level of hepatocyte proliferation (labelling index 4–32%) was observed to peak between 24 and 48 h and return to control values by 8 days. In every case, a peak in myc expression was seen between 0.5 and 18 h depending on the proliferative stimulus treatment. A large peak infos expression was seen at 0.5–2 h but only with the cytotoxic and regenerative proliferative treatments partial hepatectomy or carbon tetrachloride. A broad peak in Ha‐ras expression was observed 12 to 36 h after each treatment. These data demonstrate transient expression of these genes following the synchronous induction of hepatocyte proliferation. The increased expression offos upon treatment with cytotoxicants, but not mitogens, suggests different modes of growth regulation that may be important in understanding the induction of cell proliferation by these two types of agents.
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细胞增殖和促进大鼠肝癌发生：肝再生和丝裂原诱导的增生对酶改变病灶发展的不同影响。
影响因子：
4.7
作者：
Columbano,A;Ledda-Columbano,GM;Ennas,MG;Curto,M;Chelo,A;Pani,P
通讯作者：
Pani,P
进一步的证据表明，丝裂原诱导的细胞增殖并不支持致癌物在大鼠肝脏中形成酶改变岛。
影响因子：
4.7
作者：
Ledda-Columbano,GM;Columbano,A;Curto,M;Ennas,MG;Coni,P;Sarma,DS;Pani,P
通讯作者：
Pani,P
肝脏生长的调节：原癌基因和转化生长因子。
DOI：
--
发表时间：
1989
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
Fausto,N;Mead,JE
通讯作者：
Mead,JE
丝裂原诱导的肝细胞增殖过程中细胞周期依赖性原癌基因表达动力学的研究。
影响因子：
9.7
作者：
Coni,P;Bignone,FA;Pichiri,G;Ledda-Columbano,GM;Columbano,A;Rao,PM;Rajalakshmi,S;Sarma,DS
通讯作者：
Sarma,DS