Diagnostic Accuracy of Serum/Plasma Circular RNAs and the Combination of Circular RNAs and α-Fetoprotein for Detecting Hepatocellular Carcinoma: A Meta-Analysis.
Diagnostic Accuracy of Serum/Plasma Circular RNAs and the Combination of Circular RNAs and α-Fetoprotein for Detecting Hepatocellular Carcinoma: A Meta-Analysis.
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血清/血浆环状 RNA 以及环状 RNA 与甲胎蛋白组合检测肝细胞癌的诊断准确性：荟萃分析
DOI：
10.3389/fgene.2021.722208
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发表时间：
2021
影响因子：
3.7
通讯作者：
Cheng N
中科院分区：
文献类型：
--
作者：
Nie G;Peng D;Li B;Lu J;Cai Y;Xiong X;Cheng N
肝细胞癌（HCC）缺乏准确的生物标志物，阻碍了早期检测，诊断和治疗。随着分子生物标志物研究的深入和基因组医学的发展，环状RNA（circular RNA，circRNA）作为一种新的生物标志物在液体活检中的应用日益受到关注。我们对血清/血浆circRNA或circRNA与甲胎蛋白（AFP）联合诊断HCC的准确性进行了荟萃分析。我们从PubMed、Web of Science、EMBASE和科克伦图书馆数据库中确定了8项符合纳入/排除标准的研究。合并数据，计算灵敏度、特异性、诊断比值比（DOR）、阳性似然比（+LR）和阴性似然比（-LR）及其95%置信区间（CI）。还计算了受试者工作特征（SROC）曲线（AUC）下的面积。circRNA的敏感性为0.82（95%CI：0.78-0.85），特异性为0.82（95%CI：0.78-0.86）。AFP检测的敏感性为0.65（95% CI：0.61-0.68），特异性为0.90（95% CI：0.85-0.93）。circRNA的AUC为0.89（95% CI：0.86-0.91），AFP的AUC为0.77（95% CI：0.74-0.81）。circRNA与AFP联合检测的敏感性为0.88（95%CI：0.84-0.92），特异性为0.86（95%CI：0.80-0.91），AUC为0.94（95%CI：0.91-0.96）。此外，基于所使用的对照组进行了亚组分析;在HCC与健康对照的比较中，诊断准确性特别高。总之，血清/血浆circRNA是适合于临床用于检测HCC的准确生物标志物，并且circRNA和AFP的组合提高了诊断准确性。
The lack of an accurate biomarker in hepatocellular carcinoma (HCC) has hindered early detection, diagnosis, and treatment. Circular RNAs (circRNAs), which can be used as novel biomarkers in liquid biopsies, have been brought to light as a result of the advances in research on molecular biomarkers and the progression of genomic medicine. We conducted a meta-analysis of the diagnostic accuracy of serum/plasma circRNAs or the combination of circRNAs and α-fetoprotein (AFP) in HCC. We identified eight studies that met the inclusion/exclusion criteria from PubMed, Web of Science, EMBASE, and Cochrane Library databases. The data were pooled, and the sensitivity, specificity, diagnostic odds ratio (DOR), positive likelihood ratio (+LR), and negative likelihood ratio (-LR) with 95% confidence intervals (CIs) were calculated. The areas under the summary receiver operator characteristic (SROC) curves (AUCs) were also calculated. The sensitivity of circRNAs was 0.82 (95% CI: 0.78–0.85), and the specificity was 0.82 (95% CI: 0.78–0.86). The sensitivity of AFP was 0.65 (95% CI: 0.61–0.68), and the specificity was 0.90 (95% CI: 0.85–0.93). The AUC was 0.89 (95% CI: 0.86–0.91) for circRNAs and 0.77 (95% CI: 0.74–0.81) for AFP. The sensitivity of the combination of circRNAs and AFP was 0.88 (95% CI: 0.84–0.92), specificity was 0.86 (95% CI: 0.80–0.91), and AUC was 0.94 (95% CI: 0.91–0.96). Additionally, a subgroup analysis was conducted based on the control groups used; the diagnostic accuracy was particularly high in the comparison of HCC vs. healthy controls. In summary, serum/plasma circRNAs are accurate biomarkers suitable for clinical use for detecting HCC, and the combination of circRNAs and AFP improved the diagnostic accuracy.
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影响因子：
51.1
作者：
Oberg, Kjell;Modlin, Irvin M.;De Herder, Wouter;Pavel, Marianne;Klimstra, David;Frilling, Andrea;Metz, David C.;Heaney, Anthony;Kwekkeboom, Dik;Strosberg, Jonathan;Meyer, Timothy;Moss, Steven F.;Washington, Kay;Wolin, Edward;Liu, Eric;Goldenring, James
通讯作者：
Goldenring, James
影响因子：
10.3
作者：
Lee, Yi-Te;Wang, Jasmine J.;Yang, Ju Dong
通讯作者：
Yang, Ju Dong
影响因子：
4
作者：
Huang, Xin;Zhang, Weiyue;Shao, Zengwu
通讯作者：
Shao, Zengwu
影响因子：
4
作者：
Hang D;Zhou J;Qin N;Zhou W;Ma H;Jin G;Hu Z;Dai J;Shen H
通讯作者：
Shen H
影响因子：
13.5
作者：
OKA, H;TAMORI, A;YAMAMOTO, S
通讯作者：
YAMAMOTO, S