Four Cases of Spontaneous Neoplasia in the Naked Mole-Rat (Heterocephalus glaber), A Putative Cancer-Resistant Species.
Four Cases of Spontaneous Neoplasia in the Naked Mole-Rat (Heterocephalus glaber), A Putative Cancer-Resistant Species.
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裸鼹鼠（Heterocephalus glaber）自发性肿瘤的四例，一种假定的抗癌物种。
DOI：
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
C. Rodríguez
中科院分区：
文献类型：
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作者：
K. Taylor;N. A. Milone;C. Rodríguez
裸鼹鼠（Heterocephalus glaber）被广泛认为具有抗癌性，并且基于该物种肿瘤发生的报道较少而引起了相当大的研究兴趣。然而，我们在动物园收集的一对非杂交裸鼹鼠中，通过常规尸检和活检发现了4例自发瘤变和1例推定瘤变。在1998年至2015年8月间提交的37例1岁以上裸鼹鼠非自溶尸检中，发现了转移性肝细胞癌、肾母细胞瘤（Wilms肿瘤）、多中心淋巴肉瘤以及推定的食管腺癌（Barrett食管样）各1例。一个偶然的皮肤血管瘤病例也被鉴定为死前的皮肤活检从一个裸鼹鼠检查外伤。
The naked mole-rat (Heterocephalus glaber) is widely acclaimed to be cancer-resistant and of considerable research interest based on a paucity of reports of neoplasia in this species. We have, however, encountered four spontaneous cases of neoplasia and one presumptive case of neoplasia through routine necropsy and biopsy of individuals in a zoo collection of nonhybrid naked mole-rats bred from a single pair. One case each of metastasizing hepatocellular carcinoma, nephroblastoma (Wilms' tumor), and multicentric lymphosarcoma, as well as presumptive esophageal adenocarcinoma (Barrett's esophagus-like) was identified postmortem among 37 nonautolyzed necropsy submissions of naked mole-rats over 1-year-old that were submitted for necropsy between 1998 and August 2015. One incidental case of cutaneous hemangioma was also identified antemortem by skin biopsy from one naked mole-rat examined for trauma.
DOI：
10.1093/gerona/glr222
发表时间：
2012-04-01
影响因子：
5.1
作者：
Grimes, Kelly M.;Lindsey, Merry L.;Buffenstein, Rochelle
通讯作者：
Buffenstein, Rochelle
DOI：
10.1093/gerona/60.11.1369
发表时间：
2005-11-01
影响因子：
5.1
作者：
Buffenstein, R
通讯作者：
Buffenstein, R