Microstructural alterations in medial forebrain bundle are associated with interindividual pain sensitivity.
Microstructural alterations in medial forebrain bundle are associated with interindividual pain sensitivity.
复制标题
内侧前脑束的微结构改变与个体间疼痛敏感性有关。
DOI：
10.1002/hbm.25281
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发表时间：
2021-03
影响因子：
4.8
通讯作者：
Kikinis Z
中科院分区：
文献类型：
--
作者：
Geisler M;Rizzoni E;Makris N;Pasternak O;Rathi Y;Bouix S;Herbsleb M;Bär KJ;Weiss T;Kikinis Z
The perception of pain to noxious stimuli, also known as pain sensitivity, varies among individuals. The comprised brain structures and their white matter pathways are complex and elusive. Here, we aimed to investigate whether variation of microstructure of the medial forebrain bundle (MFB), a tract connecting the basal forebrain with the brain stem, is associated with interindividual pain sensitivity. We assessed interindividual pain sensitivity as a rating of pain intensity to heat stimuli (45, 47, and 48.9°C) in 38 healthy men (age: 27.05 ± 5.7 years). We also reconstructed the MFB using multitensor tractography from diffusion magnetic resonance imaging (dMRI) and calculated free‐water corrected dMRI measures of fractional anisotropy (FAt), radial diffusivity (RDt), and axial diffusivity (ADt). Lower ratings of interindividual pain intensity correlated with higher FAt and lower RDt of the MFB. As changes in FAt and RDt may reflect abnormalities in myelination, the results might be interpreted as that a lower pain rating is associated with higher degree of myelination of the MFB and could represent an inhibitory pathway of pain. Our results suggest that alteration of microstructure in the MFB contributes to the interindividual variation of pain perception. We aimed to investigate whether variation of microstructure of the medial forebrain bundle (MFB) is associated with interindividual pain sensitivity, by assessing interindividual pain sensitivity as a rating of pain intensity to heat stimuli and reconstructing the MFB using multitensor tractography from diffusion magnetic resonance imaging (dMRI) in 38 healthy men. Lower ratings of interindividual pain intensity correlated with higher fractional anisotropy (FAt) and lower radial diffusivity (RDt) of the MFB. As changes in FAt and RDt may reflect abnormalities in myelination, the results might be interpreted as that a lower pain rating is associated with higher degree of myelination of the MFB and could represent an inhibitory pathway of pain.
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影响因子：
7.4
作者：
Campbell, CM;Edward, RR;Fillingim, RB
通讯作者：
Fillingim, RB
影响因子：
4.8
作者：
Calabrese E;Hickey P;Hulette C;Zhang J;Parente B;Lad SP;Johnson GA
通讯作者：
Johnson GA
影响因子：
5.7
作者：
Linnman, Clas;Moulton, Eric A.;Barmettler, Gabi;Becerra, Lino;Borsook, David
通讯作者：
Borsook, David
DOI：
10.1016/j.jmr.2011.09.022
发表时间：
1996-06-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
Basser, PJ;Pierpaoli, C
通讯作者：
Pierpaoli, C
影响因子：
7.7
作者：
Grahl A;Onat S;Büchel C
通讯作者：
Büchel C