Neuroimaging of the periaqueductal gray: state of the field.
Neuroimaging of the periaqueductal gray: state of the field.
复制标题
DOI：
10.1016/j.neuroimage.2011.11.095
复制
发表时间：
2012-03
期刊：
影响因子：
5.7
通讯作者：
Borsook, David
中科院分区：
文献类型：
--
作者：
Linnman, Clas;Moulton, Eric A.;Barmettler, Gabi;Becerra, Lino;Borsook, David
本综述和荟萃分析旨在总结和整合报告导水管周围灰质（PAG）受累的人类神经影像学研究；已确定 250 份有关 PAG 人类神经影像学的原始手稿。包括使用激活可能性估计的叙述性回顾和荟萃分析。涵盖的行为包括疼痛和疼痛调节、焦虑、膀胱和肠道功能以及自主调节。方法包括结构和功能磁共振成像、功能连接测量、扩散加权成像和正电子发射断层扫描。对健康和临床人群的人类神经影像学研究在很大程度上证实了动物文献表明 PAG 参与重要功能（如疼痛、焦虑和自主神经功能）的稳态调节。讨论了当前文献中的方法论问题，包括分辨率限制、成像伪影和不精确的神经解剖学标记，并提出了未来的方向。总体结论是，PAG 神经影像学是一个具有将动物数据转化为人类行为的巨大潜力的领域，但也存在一些可以而且需要解决的成长难题，以增加我们对这一关键区域神经生物学的理解。
This review and meta-analysis aims at summarizing and integrating the human neuroimaging studies that report periaqueductal gray (PAG) involvement; 250 original manuscripts on human neuroimaging of the PAG were identified. A narrative review and meta-analysis using activation likelihood estimates is included. Behaviors covered include pain and pain modulation, anxiety, bladder and bowel function and autonomic regulation. Methods include structural and functional magnetic resonance imaging, functional connectivity measures, diffusion weighted imaging and positron emission tomography. Human neuroimaging studies in healthy and clinical populations largely confirm the animal literature indicating that the PAG is involved in homeostatic regulation of salient functions such as pain, anxiety and autonomic function. Methodological concerns in the current literature, including resolution constraints, imaging artifacts and imprecise neuroanatomical labeling are discussed, and future directions are proposed. A general conclusion is that PAG neuroimaging is a field with enormous potential to translate animal data onto human behaviors, but with some growing pains that can and need to be addressed in order to add to our understanding of the neurobiology of this key region.
登录
查看更多内容
影响因子：
5.7
作者：
Beacher, Felix D. C. C.;Gray, Marcus A.;Mathias, Christopher J.;Critchley, Hugo D.
通讯作者：
Critchley, Hugo D.
影响因子：
7.4
作者：
Bingel, U;Lorenz, J;Büchel, C
通讯作者：
Büchel, C
影响因子：
14.5
作者：
Athwal, BS;Berkley, KJ;Fowler, CJ
通讯作者：
Fowler, CJ
影响因子：
5.7
作者：
Aron, AR;Gluck, MA;Poldrack, RA
通讯作者：
Poldrack, RA
影响因子：
29.4
作者：
Berman, SM;Chang, L;Mayer, EA
通讯作者：
Mayer, EA