Beyond Agrobacterium-Mediated Transformation: Horizontal Gene Transfer from Bacteria to Eukaryotes.
Beyond Agrobacterium-Mediated Transformation: Horizontal Gene Transfer from Bacteria to Eukaryotes.
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DOI：
10.1007/82_2018_82
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发表时间：
2018
影响因子：
--
通讯作者：
Citovsky, Vitaly
中科院分区：
文献类型：
--
作者：
Lacroix, Benoit;Citovsky, Vitaly
除了真核生物早期进化过程中细胞器向核基因组的大量基因转移外，水平基因转移（HGT）在真核生物中的重要性一直存在争议。然而，越来越多的基因组数据揭示了许多细菌到真核生物HGT的案例，这些案例可能代表了真核生物物种适应性进化的重要力量。然而，传统上认为农杆菌属植物遗传转化中涉及的DNA转移是天然DNA转移和整合到真核基因组中的唯一例子。最近的发现表明，供体细菌物种和受体真核宿主的库可能比以前认为的要广泛得多，包括供体细菌物种，如植物共生固氮细菌（例如，根瘤菌（Rhizobium etli）和动物细菌病原体（例如，巴尔通体（Bartonella henselae）、幽门螺杆菌（Helicobacter pylori）和来自几乎所有真核生物分支的受体物种。在这里，我们综述了这些跨王国HGT事件的分子途径和潜在机制，并讨论了它们在生物技术和研究中的应用。
Besides the massive gene transfer from organelles to the nuclear genomes, which occurred during the early evolution of eukaryote lineages, the importance of horizontal gene transfer (HGT) in eukaryotes remains controversial. Yet, increasing amounts of genomic data reveal many cases of bacterium-to-eukaryote HGT that likely represent a significant force in adaptive evolution of eukaryotic species. However, DNA transfer involved in genetic transformation of plants by Agrobacterium species has traditionally been considered as the unique example of natural DNA transfer and integration into eukaryotic genomes. Recent discoveries indicate that the repertoire of donor bacterial species and of recipient eukaryotic hosts potentially are much wider than previously thought, including donor bacterial species, such as plant symbiotic nitrogen-fixing bacteria (e.g., Rhizobium etli) and animal bacterial pathogens (e.g., Bartonella henselae, Helicobacter pylori), and recipient species from virtually all eukaryotic clades. Here, we review the molecular pathways and potential mechanisms of these trans-kingdom HGT events and discuss their utilization in biotechnology and research.
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