Age-matched comparison of children hospitalized for 2009 pandemic H1N1 influenza with those hospitalized for seasonal H1N1 and H3N2.
Age-matched comparison of children hospitalized for 2009 pandemic H1N1 influenza with those hospitalized for seasonal H1N1 and H3N2.
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2009年大流行H1N1流感的儿童与季节性H1N1和H3N2住院的儿童的年龄匹配比较。
DOI：
10.1371/journal.pone.0021837
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Peiris JS
中科院分区：
文献类型：
--
作者：
Chiu SS;Chan KH;Wong WH;Chan EL;Peiris JS
据报道，感染2009年大流行性H1N1（pH1N1）流感的儿童出现了从死亡到轻度病程的广泛临床表现。我们进行了一项年龄匹配的对照研究，比较了因pH1N1住院的儿童与感染季节性H1N1和H3N2流感的历史对照，以纠正年龄对疾病易感性和临床表现的影响。我们还比较了pH1N1儿童与大流行期间因季节性流感同时入院的儿童，以调整大流行期间寻求健康行为的差异或与历史对照相关的其他潜在偏倚。无死亡或重症监护入院。pH1N1的儿童更有可能至少有一种流感风险状况，一种潜在的慢性肺部疾病，更有可能发生哮喘急性发作并接受奥司他韦治疗。在临床过程或结果的其他方面没有差异。在我们的患者人群中，因pH1N1感染住院的儿童的疾病表现较轻。
A wide spectrum of clinical manifestation ranging from deaths to a mild course of disease has been reported in children infected with the 2009 pandemic H1N1 (pH1N1) influenza. We conducted an age-matched control study comparing children hospitalized for pH1N1 with historic controls infected with seasonal H1N1 and H3N2 influenza to correct for the effect of age on disease susceptibility and clinical manifestations. We also compared children with pH1N1 to children concurrently admitted for seasonal influenza during the pandemic period to adjust for differences in health-seeking behavior during the pandemic or other potential bias associated with historic controls. There was no death or intensive care admission. Children with pH1N1 were more likely to have at least one risk condition for influenza, an underlying chronic pulmonary condition, more likely to have asthma exacerbation and to be treated with oseltamivir. There was no difference in other aspects of the clinical course or outcome. Disease manifestation of children hospitalized for pH1N1 infection was mild in our patient population.
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