High expression of UNC5B enhances tumor proliferation, increases metastasis, and worsens prognosis in breast cancer.
High expression of UNC5B enhances tumor proliferation, increases metastasis, and worsens prognosis in breast cancer.
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UNC5B的高表达会增强乳腺癌的肿瘤增殖、增加转移并恶化预后
DOI：
10.18632/aging.103639
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发表时间：
2020-09-09
期刊：
影响因子：
--
通讯作者：
Chen Y
中科院分区：
文献类型：
--
作者：
Wu S;Guo X;Zhou J;Zhu X;Chen H;Zhang K;Lu Y;Chen Y
β-5同系物B（UNC 5 B）是依赖性受体家族的成员，其以配体依赖性方式调节细胞存活和凋亡。UNC 5 B在多种癌症的发展中起重要作用，包括结肠直肠癌、膀胱癌和甲状腺癌。然而，UNC 5 B在乳腺癌中的确切表达模式和机制尚未得到很好的阐明。在这里，我们使用生物信息学分析和实验验证表明，UNC 5 B表达在乳腺癌中显著上调。高UNC 5 B表达与乳腺癌患者的总体生存率相关。UNC 5 B敲低抑制乳腺癌细胞增殖和转移，并损害PI 3 K/Akt信号转导激活。总之，UNC 5 B是一种有前途的诊断和预后生物标志物，靶向UNC 5 B是个体化乳腺癌治疗的潜在策略。
UNC-5 Homolog B (UNC5B) is a member of the dependence receptor family that regulates cell survival and apoptosis in a ligand-dependent manner. UNC5B plays an important role in the development of multiple cancers, including colorectal, bladder, and thyroid cancer. However, the exact expression pattern and mechanism of UNC5B in breast cancer have not been well elucidated. Here, we showed that UNC5B expression was significantly upregulated in breast cancer using bioinformatics analysis and experimental validation. High UNC5B expression was correlated with poor overall survival in breast cancer patients. UNC5B knockdown inhibited breast cancer cell proliferation and metastasis and compromised PI3K/Akt signaling activation. In summary, UNC5B is a promising diagnostic and prognostic biomarker and targeting UNC5B is a potential strategy for individualized breast cancer treatment.
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影响因子：
7.3
作者：
Gao J;Aksoy BA;Dogrusoz U;Dresdner G;Gross B;Sumer SO;Sun Y;Jacobsen A;Sinha R;Larsson E;Cerami E;Sander C;Schultz N
通讯作者：
Schultz N
膀胱癌中UNC5B表达的临床意义
影响因子：
--
作者：
Liu, Jiao;Zhang, Zhe;Kong, Chui-Ze
通讯作者：
Kong, Chui-Ze
影响因子：
168.9
作者：
Davies, C.;Godwin, J.;Gray, R.;Clarke, M.;Darby, S.;McGale, P.;Wang, Y. C.;Peto, R.;Pan, H. C.;Cutter, D.;Taylor, C.;Ingle, J.
通讯作者：
Ingle, J.
影响因子：
64.8
作者：
Karnoub, Antoine E.;Dash, Ajeeta B.;Weinberg, Robert A.
通讯作者：
Weinberg, Robert A.
影响因子：
64.8
作者：
Lu, XW;le Noble, F;Eichmann, A
通讯作者：
Eichmann, A