Calcium-Sensing Receptor in Human Peripheral Blood T Lymphocytes Is Involved in the AMI Onset and Progression through the NF-κB Signaling Pathway.
Calcium-Sensing Receptor in Human Peripheral Blood T Lymphocytes Is Involved in the AMI Onset and Progression through the NF-κB Signaling Pathway.
复制标题
人外周血 T 淋巴细胞中的钙敏感受体通过 NF-B 信号通路参与 AMI 的发生和进展
DOI：
10.3390/ijms17091397
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发表时间：
2016-08-24
影响因子：
5.6
通讯作者：
Sun YH
中科院分区：
文献类型：
--
作者：
Zeng JY;Du JJ;Pan Y;Wu J;Bi HL;Cui BH;Zhai TY;Sun Y;Sun YH
Acute myocardial infarction (AMI) is a condition triggered by an inflammatory process that seriously affects human health. Calcium-sensing receptor (CaSR) in T lymphocytes is involved during the inflammation reaction. However, the relationship between them is not very clear. In this study, we collected human peripheral blood T lymphocytes from patients with AMI and in different stages of percutaneous coronary intervention (PCI) (at the onset of AMI, the first day after PCI (PCI-1), PCI-3, and PCI-5) to study the CaSR and NF-κB pathway protein expression, cytokine release and T cell apoptosis. The results showed that the expressions of CaSR, P-p65, Caspase-12, and the secretions of Th-1 and Th-2 type cytokines were increased at the onset of AMI, especially on the PCI-1. Meanwhile, the apoptosis rate of CD3+, CD4+ and CD8+ T lymphocytes also increased. However, from PCI-3, all the indicators began to decline. In addition, we also found that positive CaSR small interfering RNA (siRNA) transfection in T lymphocytes and NF-κB pathway blocker Bay-11-7082 reversed the increased expressions of CaSR, P-p65, Caspase-12, reduced the secretions of Th-1 and Th-2 type cytokines, and decreased T lymphocytes apoptosis rate not only in the AMI patients but also in the normal controls. All of these results indicated that CaSR in the human peripheral blood T lymphocytes were involved in the AMI onset and progression, which probably was related to the NF-κB pathway. Our study demonstrated the relationship between AMI and CaSR, and will provide new effective prevention theory and new targets for drug treatment.
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影响因子：
6.1
作者：
Mine, Yoshinori;Zhang, Hua
通讯作者：
Zhang, Hua
DOI：
10.1016/j.jsbmb.2013.10.015
发表时间：
2014-10
影响因子：
4.1
作者：
Fetahua, Irfete S.;Hummel, Doris M.;Manhardt, Teresa;Aggarwal, Abhishek;Baumgartner-Parzer, Sabina;Kallay, Eniko
通讯作者：
Kallay, Eniko
影响因子：
5.4
作者：
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通讯作者：
Tan, Sheng-Yu
影响因子：
3.6
作者：
Li, Tingting;Sun, Mingrui;Sun, Yihua
通讯作者：
Sun, Yihua
影响因子：
3.5
作者：
Lu, Yongguang;Li, Lang;Fu, Chunhui
通讯作者：
Fu, Chunhui