MoS(2)-based nanocomposites for cancer diagnosis and therapy.
MoS(2)-based nanocomposites for cancer diagnosis and therapy.
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DOI：
10.1016/j.bioactmat.2021.04.021
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发表时间：
2021-11
影响因子：
18.9
通讯作者：
Ai K
中科院分区：
文献类型：
--
作者：
Wang J;Sui L;Huang J;Miao L;Nie Y;Wang K;Yang Z;Huang Q;Gong X;Nan Y;Ai K
钼是人类生存所必需的一种微量膳食元素。一些含钼酶参与人体内的关键代谢活动(如黄嘌呤氧化酶、乙醛氧化酶和亚硫酸盐氧化酶)。许多钼系化合物在生物医学研究中得到了广泛的应用。特别是MoS_2纳米材料，由于其独特的物理化学性质，近年来在癌症的诊断和治疗方面受到了越来越多的关注。MoS2易于修饰，具有较高的比表面积，可以通过共价或非共价相互作用吸附各种生物分子和药物分子，提高了其肿瘤靶向性和胶体稳定性，并提高了检测特定生物标志物的准确性和灵敏度。同时，在近红外(NIR)窗口，MoS2具有良好的光吸收和显著的光热转换效率，可以实现基于近红外的光疗和近红外响应的药物控制释放。值得注意的是，修饰后的MoS2纳米复合材料能够对肿瘤微环境进行特异性的响应，导致药物在肿瘤部位的蓄积增加，减少了其对非肿瘤组织的副作用，提高了治疗效果。本文介绍了MoS2-纳米复合材料在肿瘤诊断和治疗中的最新进展，主要集中在生物传感器、生物成像、化疗、光疗、微波热疗和联合治疗等方面。此外，我们还讨论了MoS_2-纳米复合材料在癌症治疗中的当前挑战和前景。具有较大比表面积的MoS2可以结合多种分子形成多功能纳米平台。MoS2具有优异的光吸收和光热转换效率，可用于癌症治疗和生物成像。二硫化钼纳米复合材料可以对肿瘤微环境做出特异性反应，减少对非肿瘤组织的副作用。
Molybdenum is a trace dietary element necessary for the survival of humans. Some molybdenum-bearing enzymes are involved in key metabolic activities in the human body (such as xanthine oxidase, aldehyde oxidase and sulfite oxidase). Many molybdenum-based compounds have been widely used in biomedical research. Especially, MoS2-nanomaterials have attracted more attention in cancer diagnosis and treatment recently because of their unique physical and chemical properties. MoS2 can adsorb various biomolecules and drug molecules via covalent or non-covalent interactions because it is easy to modify and possess a high specific surface area, improving its tumor targeting and colloidal stability, as well as accuracy and sensitivity for detecting specific biomarkers. At the same time, in the near-infrared (NIR) window, MoS2 has excellent optical absorption and prominent photothermal conversion efficiency, which can achieve NIR-based phototherapy and NIR-responsive controlled drug-release. Significantly, the modified MoS2-nanocomposite can specifically respond to the tumor microenvironment, leading to drug accumulation in the tumor site increased, reducing its side effects on non-cancerous tissues, and improved therapeutic effect. In this review, we introduced the latest developments of MoS2-nanocomposites in cancer diagnosis and therapy, mainly focusing on biosensors, bioimaging, chemotherapy, phototherapy, microwave hyperthermia, and combination therapy. Furthermore, we also discuss the current challenges and prospects of MoS2-nanocomposites in cancer treatment. MoS2 with a large specific surface area can combine a variety of molecules to form a multifunctional nano-platform. MoS2 with excellent optical absorption and photothermal conversion efficiency can be used in cancer therapy and bioimaging. MoS2-nanocomposite can specifically respond to the tumor microenvironment and reduce side effects on non-cancerous tissues.
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影响因子：
6.2
作者：
Bode C;Zhao G;Steinhagen F;Kinjo T;Klinman DM
通讯作者：
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影响因子：
38.3
作者：
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影响因子：
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DOI：
10.1073/pnas.0813019106
发表时间：
2009-03-17
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
10.6
作者：
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