Validating Patient-Specific Finite Element Models of Direct Electrocortical Stimulation.
Validating Patient-Specific Finite Element Models of Direct Electrocortical Stimulation.
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DOI：
10.3389/fnins.2021.691701
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发表时间：
2021
影响因子：
4.3
通讯作者：
Dorval AD
中科院分区：
文献类型：
--
作者：
Charlebois CM;Caldwell DJ;Rampersad SM;Janson AP;Ojemann JG;Brooks DH;MacLeod RS;Butson CR;Dorval AD
使用皮层电图电极的直接皮层电刺激（德克斯）是癫痫的既定疗法，也是中风康复和脑机接口的新兴应用。然而，导致治疗效果的电生理机制仍不清楚。患者特定的计算模型是预测大脑中的电压并更好地理解对德克斯的神经和临床反应的有希望的工具，但这种模型的准确性尚未在人类中直接验证。模拟德克斯的一个关键障碍是由于电极植入后大脑移位而将电极准确定位在皮质表面上。尽管脑移位引入了固有的不确定性，电极定位参数的影响还没有被调查。本研究的目的是验证德克斯患者特定的计算模型对德克斯过程中获得的体内电压记录，并量化电极定位参数对皮质表面模拟电压的影响。我们在德克斯期间测量了六名癫痫患者的颅内电压，并研究了以下电极定位参数：主轴、爱马仕和Dykstra电极投影方法，结合电极下方0、1和2 mm的脑脊髓液（CSF）。电极和皮质表面之间的CSF深度越大，模型误差越大，预测电压准确度越低。最佳估计6名具有不同脑移位量的患者的记录电压的电极定位参数是爱马仕投影法和0 mm的CSF深度（r = 0.92，线性回归斜率= 1.21）。这些结果是第一个量化电极定位参数与体内颅内记录的影响，并可能作为未来研究的基础，调查癫痫，中风和其他新兴的闭环应用的德克斯的神经元和临床效果。
Direct electrocortical stimulation (DECS) with electrocorticography electrodes is an established therapy for epilepsy and an emerging application for stroke rehabilitation and brain-computer interfaces. However, the electrophysiological mechanisms that result in a therapeutic effect remain unclear. Patient-specific computational models are promising tools to predict the voltages in the brain and better understand the neural and clinical response to DECS, but the accuracy of such models has not been directly validated in humans. A key hurdle to modeling DECS is accurately locating the electrodes on the cortical surface due to brain shift after electrode implantation. Despite the inherent uncertainty introduced by brain shift, the effects of electrode localization parameters have not been investigated. The goal of this study was to validate patient-specific computational models of DECS against in vivo voltage recordings obtained during DECS and quantify the effects of electrode localization parameters on simulated voltages on the cortical surface. We measured intracranial voltages in six epilepsy patients during DECS and investigated the following electrode localization parameters: principal axis, Hermes, and Dykstra electrode projection methods combined with 0, 1, and 2 mm of cerebral spinal fluid (CSF) below the electrodes. Greater CSF depth between the electrode and cortical surface increased model errors and decreased predicted voltage accuracy. The electrode localization parameters that best estimated the recorded voltages across six patients with varying amounts of brain shift were the Hermes projection method and a CSF depth of 0 mm (r = 0.92 and linear regression slope = 1.21). These results are the first to quantify the effects of electrode localization parameters with in vivo intracranial recordings and may serve as the basis for future studies investigating the neuronal and clinical effects of DECS for epilepsy, stroke, and other emerging closed-loop applications.
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影响因子：
--
作者：
Fiocchi S;Chiaramello E;Ravazzani P;Parazzini M
通讯作者：
Parazzini M
影响因子：
25
作者：
Dadarlat, Maria C.;O'Doherty, Joseph E.;Sabes, Philip N.
通讯作者：
Sabes, Philip N.
深脑刺激过程中产生的激活量的概率分析。
影响因子：
5.7
作者：
Butson CR;Cooper SE;Henderson JM;Wolgamuth B;McIntyre CC
通讯作者：
McIntyre CC
影响因子：
1.7
作者：
BERGER, MS;OJEMANN, GA
通讯作者：
OJEMANN, GA
影响因子：
3
作者：
Dalal, Sarang S.;Edwards, Erik;Kirsch, Heidi E.;Barbaro, Nicholas M.;Knight, Robert T.;Nagarajan, Srikantan S.
通讯作者：
Nagarajan, Srikantan S.