Cataract Development by Exposure to Ultraviolet and Blue Visible Light in Porcine Lenses.
Cataract Development by Exposure to Ultraviolet and Blue Visible Light in Porcine Lenses.
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DOI：
10.3390/medicina57060535
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发表时间：
2021-05-27
期刊：
影响因子：
--
通讯作者：
Heßling M
中科院分区：
文献类型：
--
作者：
Haag R;Sieber N;Heßling M
背景与目的：白内障仍是致盲的主要原因。它的发展是很好的研究紫外线辐射。LED和显示器等现代光源倾向于发出蓝光。蓝光对视网膜的影响被称为蓝光危害，并被广泛研究。然而，其对透镜的影响迄今尚未研究。目的：研究与UVA和UVB辐射相比，蓝色可见光对猪透镜的影响。材料与方法：在该离体实验中，以6 kJ/cm 2的剂量在311 nm（UVB）、370 nm（UVA）和460 nm（蓝光）的波长下照射猪晶状体。辐照前后的透镜透射率测量可以深入了解辐射的影响。此外，在照射之前和之后从每个透镜拍摄暗场图像。白内障的发展是由直方图线性化以及记录的暗场图像的故障着色说明。通过对背景原始图像中的透镜进行分割，可以比较照射前后的透镜状态。结果：所有经6 kJ/cm 2辐照的晶状体均显示在311 nm、370 nm和460 nm辐照下发生白内障。两种评价均显示460 nm照射引起的白内障最多。结论：所有研究的辐射源都能引起猪晶状体白内障，即使是蓝色可见光。
Background and Objectives: Cataract is still the leading cause of blindness. Its development is well researched for UV radiation. Modern light sources like LEDs and displays tend to emit blue light. The effect of blue light on the retina is called blue light hazard and is studied extensively. However, its impact on the lens is not investigated so far. Aim: Investigation of the impact of the blue visible light in porcine lens compared to UVA and UVB radiation. Materials and Methods: In this ex-vivo experiment, porcine lenses are irradiated with a dosage of 6 kJ/cm2 at wavelengths of 311 nm (UVB), 370 nm (UVA), and 460 nm (blue light). Lens transmission measurements before and after irradiation give insight into the impact of the radiation. Furthermore, dark field images are taken from every lens before and after irradiation. Cataract development is illustrated by histogram linearization as well as faults coloring of recorded dark field images. By segmenting the lens in the background’s original image, the lens condition before and after irradiation could be compared. Results: All lenses irradiated with a 6 kJ/cm2 reveal cataract development for radiation with 311 nm, 370 nm, and 460 nm. Both evaluations reveal that the 460 nm irradiation causes the most cataract. Conclusion: All investigated irradiation sources cause cataracts in porcine lenses—even blue visible light.
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影响因子：
7.4
作者：
Li, WC;Spector, A
通讯作者：
Spector, A
影响因子：
3.3
作者：
Fuentealba, Denis;Friguet, Bertrand;Silva, Eduardo
通讯作者：
Silva, Eduardo
影响因子：
4.1
作者：
BESWICK, HT;HARDING, JJ
通讯作者：
HARDING, JJ
影响因子：
2.1
作者：
Dong, XQ;Söderberg, PG;Löfgren, S
通讯作者：
Löfgren, S
眼镜蛋白的色氨酸和非色氨酸荧光在分子水平上提供白内障的诊断。
影响因子：
4.6
作者：
Gakamsky A;Duncan RR;Howarth NM;Dhillon B;Buttenschön KK;Daly DJ;Gakamsky D
通讯作者：
Gakamsky D