Non-Celiac Gluten sensitivity: the new frontier of gluten related disorders.
Non-Celiac Gluten sensitivity: the new frontier of gluten related disorders.
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DOI：
10.3390/nu5103839
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发表时间：
2013-09-26
期刊：
影响因子：
5.9
通讯作者：
Fasano A
中科院分区：
文献类型：
--
作者：
Catassi C;Bai JC;Bonaz B;Bouma G;Calabrò A;Carroccio A;Castillejo G;Ciacci C;Cristofori F;Dolinsek J;Francavilla R;Elli L;Green P;Holtmeier W;Koehler P;Koletzko S;Meinhold C;Sanders D;Schumann M;Schuppan D;Ullrich R;Vécsei A;Volta U;Zevallos V;Sapone A;Fasano A
非乳糜泻谷蛋白敏感性（NCGS）最初在20世纪80年代被描述，并且最近是一种“重新发现的”病症，其特征在于在未受乳糜泻（CD）或小麦过敏（WA）影响的受试者中与摄入含谷蛋白食物相关的肠内和肠外症状。虽然NCGS的频率仍然不清楚，但已经产生了流行病学数据，可以帮助确定问题的严重性。临床研究进一步定义了NCGS的身份及其对人类疾病的影响。肠易激综合征（IBS）和NCGS之间的重叠已被检测到，需要更严格的诊断标准。一些研究表明NCGS和神经精神疾病之间的关系，特别是自闭症和精神分裂症。已描述了儿童NCGS的首例病例报告。缺乏生物标志物仍然是临床研究的主要限制，使得难以区分NCGS与其他谷蛋白相关疾病。最近的研究提出了一种可能性，即除了麸质，小麦淀粉酶-胰蛋白酶抑制剂和低发酵，吸收不良，短链碳水化合物可能导致NCGS患者经历的症状（至少与IBS相关的症状）。在本文中，我们报告的主要进展和当前的趋势NCGS。
Non Celiac Gluten sensitivity (NCGS) was originally described in the 1980s and recently a “re-discovered” disorder characterized by intestinal and extra-intestinal symptoms related to the ingestion of gluten-containing food, in subjects that are not affected with either celiac disease (CD) or wheat allergy (WA). Although NCGS frequency is still unclear, epidemiological data have been generated that can help establishing the magnitude of the problem. Clinical studies further defined the identity of NCGS and its implications in human disease. An overlap between the irritable bowel syndrome (IBS) and NCGS has been detected, requiring even more stringent diagnostic criteria. Several studies suggested a relationship between NCGS and neuropsychiatric disorders, particularly autism and schizophrenia. The first case reports of NCGS in children have been described. Lack of biomarkers is still a major limitation of clinical studies, making it difficult to differentiate NCGS from other gluten related disorders. Recent studies raised the possibility that, beside gluten, wheat amylase-trypsin inhibitors and low-fermentable, poorly-absorbed, short-chain carbohydrates can contribute to symptoms (at least those related to IBS) experienced by NCGS patients. In this paper we report the major advances and current trends on NCGS.
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DOI：
10.1084/jem.20102660
发表时间：
2012-12-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Junker Y;Zeissig S;Kim SJ;Barisani D;Wieser H;Leffler DA;Zevallos V;Libermann TA;Dillon S;Freitag TL;Kelly CP;Schuppan D
通讯作者：
Schuppan D
影响因子：
1.4
作者：
Batista, Icaro Camargo;Gandolfi, Lenora;Pratesi, Riccardo
通讯作者：
Pratesi, Riccardo
影响因子：
6.6
作者：
Cascella, Nicola G.;Kryszak, Debra;Eaton, William W.
通讯作者：
Eaton, William W.
影响因子：
1.9
作者：
Breckan, Ragnar K.;Asfeldt, Anne Mette;Paulssen, Eyvind J.
通讯作者：
Paulssen, Eyvind J.
影响因子：
9.8
作者：
Biesiekierski, Jessica R.;Newnham, Evan D.;Gibson, Peter R.
通讯作者：
Gibson, Peter R.