Rotary Nanomotors in the Rear View Mirror.

Rotary Nanomotors in the Rear View Mirror.
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DOI:
10.3389/fmicb.2022.873573
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发表时间:
2022
影响因子:
5.2
通讯作者:
--
中科院分区:
生物学2区
文献类型:
--
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旋转是我们日常生活的一部分。在人类历史的大部分时间里,旋转被认为是人类独有的发明,超出了生物体的解剖能力。 1973年,霍华德·伯格提出了一个大胆的提议:常见的肠道细菌大肠杆菌通过旋转螺旋鞭毛丝来游动。 1987年,Paul Boyer提出大肠杆菌的FoF1 ATP合酶也是一个旋转装置。现在我们知道旋转纳米机器至少独立进化了三次。它们为多种细胞过程提供动力。在此,对大肠杆菌鞭毛旋转的研究进行简要总结。 2020年,描述了细菌鞭毛MotAB定子元件的冷冻电镜结构。该结构强烈表明 MotAB 定子旋转以驱动鞭毛旋转。类似的电机可以与其他不同的过程耦合。本期的以下文章回顾了当前有关旋转生物纳米机器的知识和推测。
Rotation is part of our everyday lives. For most of human history, rotation was considered a uniquely human invention, something beyond the anatomical capabilities of organisms. In 1973, Howard Berg made the audacious proposal that the common gut bacterium Escherichia coli swims by rotating helical flagellar filaments. In 1987, Paul Boyer suggested that the FoF1 ATP synthase of E. coli is also a rotary device. Now we know that rotating nanomachines evolved independently at least three times. They power a wide variety of cellular processes. Here, the study of flagellar rotation in E. coli is briefly summarized. In 2020, the Cryo-EM structure of the MotAB stator element of the bacterial flagellum was described. The structure strongly suggests that the MotAB stator rotates to drive flagellar rotation. Similar motors are coupled to other diverse processes. The following articles in this issue review the current knowledge and speculation about rotating biological nanomachines.
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发表时间: 2020-12
影响因子: 28.3
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发表时间: 1973-01-01
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发表时间: 1973-01-01
期刊: NATURE
影响因子: 64.8
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发表时间: 1984-01-01
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影响因子: 64.8
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