Neurobehavioral and Clinical Comorbidities in Epilepsy: The Role of White Matter Network Disruption.
Neurobehavioral and Clinical Comorbidities in Epilepsy: The Role of White Matter Network Disruption.
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DOI：
10.1177/10738584221076133
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发表时间：
2024-02
期刊：
影响因子：
5.6
通讯作者：
McDonald, Carrie R.
中科院分区：
文献类型：
--
作者：
Stasenko, Alena;Lin, Christine;Bonilha, Leonardo;Bernhardt, Boris C.;McDonald, Carrie R.
癫痫是一种常见的神经系统疾病，与大脑皮层和皮层下网络的改变有关。尽管历史上关注的是涉及癫痫发作产生和传播的灰质区域，但白质（WM）网络破坏在癫痫及其合并症中的作用最近引起了人们的关注。在这篇综述中，我们描述了局灶性和全面性癫痫综合征中观察到的WM改变模式，并强调了WM破坏与认知和精神合并症、耐药性和不良手术结果之间的联系。基于束和基于连接体的方法都暗示了颞外和颞边缘WM断开在一系列合并症中的重要性，并且不断发展的文献揭示了WM模式在预测癫痫手术后预后方面的效用。我们鼓励采用先进分析技术（如机器学习）的新研究，这将进一步形成我们对癫痫作为一种网络障碍的理解，并指导个性化治疗决策。我们还解决了研究神经调节和其他治疗（如激光消融）如何影响WM网络的研究需求，以及利用更大、更多样化的样本、纵向设计和改进MRI采集的研究需求。这些步骤对于确保当前研究的普遍性和确定WM网络中的神经可塑性对患者预后的影响程度至关重要。
Epilepsy is a common neurological disorder associated with alterations in cortical and subcortical brain networks. Despite a historical focus on gray matter regions involved in seizure generation and propagation, the role of white matter (WM) network disruption in epilepsy and its comorbidities has sparked recent attention. In this review, we describe patterns of WM alterations observed in focal and generalized epilepsy syndromes and highlight studies linking WM disruption to cognitive and psychiatric comorbidities, drug-resistance and poor surgical outcomes. Both tract-based and connectome-based approaches implicate the importance of extratemporal and temporo-limbic WM disconnection across a range of comorbidities, and an evolving literature reveals the utility of WM patterns for predicting outcomes following epilepsy surgery. We encourage new research employing advanced analytic techniques (e.g., machine learning) that will further shape our understanding of epilepsy as a network disorder and guide individualized treatment decisions. We also address the need for research that examines how neuromodulation and other treatments (e.g., laser ablation) impact WM networks, as well as research that leverages larger and more diverse samples, longitudinal designs, and improved MRI acquisitions. These steps will be critical to ensuring generalizability of current research and determining the extent to which neuroplasticity within WM networks can influence patient outcomes.
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局灶性癫痫中的纤维球白质建模。
影响因子：
4.8
作者：
Bryant L;McKinnon ET;Taylor JA;Jensen JH;Bonilha L;de Bezenac C;Kreilkamp BAK;Adan G;Wieshmann UC;Biswas S;Marson AG;Keller SS
通讯作者：
Keller SS
影响因子：
4.6
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David B;Eberle J;Delev D;Gaubatz J;Prillwitz CC;Wagner J;Schoene-Bake JC;Luechters G;Radbruch A;Wabbels B;Schramm J;Weber B;Surges R;Elger CE;Rüber T
通讯作者：
Rüber T
钩束异常与左颞叶癫痫患者执行功能障碍相关
影响因子：
2.5
作者：
Diao, Limei;Yu, Haichun;Yu, Lu
通讯作者：
Yu, Lu
DOI：
10.3174/ajnr.a1650
发表时间：
2009-10
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Ahmadi ME;Hagler DJ Jr;McDonald CR;Tecoma ES;Iragui VJ;Dale AM;Halgren E
通讯作者：
Halgren E
影响因子：
5.6
作者：
Doherty C;Nowacki AS;Pat McAndrews M;McDonald CR;Reyes A;Kim MS;Hamberger M;Najm I;Bingaman W;Jehi L;Busch RM
通讯作者：
Busch RM