Untargeted Metabolite Profiling of Adipose Tissue in Rats Exposed to Mepiquat.
Untargeted Metabolite Profiling of Adipose Tissue in Rats Exposed to Mepiquat.
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暴露于甲哌快的大鼠脂肪组织的非目标代谢物分析
DOI：
10.3390/foods12040867
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发表时间：
2023-02-17
期刊：
影响因子：
--
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中科院分区：
文献类型：
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Mepiquat（Mep）是在典型的烘焙条件下，特别是在200-240 °C的范围内，通过与还原糖、游离赖氨酸和烷基化剂的美拉德反应产生的污染物。据报道，暴露于Mep对大鼠有害。但其代谢机制尚不清楚。在这项研究中，非靶向代谢组学用于揭示Mep对Sprague-Dawley大鼠脂肪组织代谢谱的影响。筛选出26个差异代谢产物。发现了8条主要的代谢途径，即亚油酸代谢，苯丙氨酸、酪氨酸和色氨酸生物合成，苯丙氨酸代谢，花生四烯酸代谢，甘氨酸、丝氨酸和苏氨酸代谢，甘油脂质代谢，丙氨酸、天冬氨酸和谷氨酸代谢，乙醛酸和二羧酸代谢。本研究为阐明Mep的毒性机制奠定了基础。
Mepiquat (Mep) is a contaminant produced by Maillard reaction with reducing sugar, free lysine and an alkylating agent under typical roasting conditions, particularly in the range of 200–240 °C. It has been reported that exposure to Mep is harmful to rats. However, its metabolic mechanism is still not clear. In this study, untargeted metabolomics was used to reveal the effect of Mep on the metabolic profile of adipose tissue in Sprague-Dawley rats. Twenty-six differential metabolites were screened out. Eight major perturbed metabolic pathways were found, which were linoleic acid metabolism, Phenylalanine, tyrosine, and tryptophan biosynthesis, phenylalanine metabolism, arachidonic acid metabolism, Glycine, serine, and threonine metabolism, glycerolipid metabolism, Alanine, aspartate, and glutamate metabolism, and glyoxylate and dicarboxylic acid metabolism. This study lays a solid foundation for clarifying the toxic mechanism of Mep.
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影响因子：
3.9
作者：
Hu, Chuanqin;Zhang, Yu;Sun, Baoguo
通讯作者：
Sun, Baoguo
影响因子：
4.4
作者：
Bispo, Daniela S. C.;Jesus, Catarina S. H.;Correia, Marlene;Ferreira, Filipa;Bonifazio, Giulia;Goodfellow, Brian J.;Oliveira, Mariana B.;Mano, Joao F.;Gil, Ana M.
通讯作者：
Gil, Ana M.
DOI：
10.1152/ajpgi.00301.2011
发表时间：
2012-01-01
影响因子：
4.5
作者：
Kakisaka, Keisuke;Cazanave, Sophie C.;Gores, Gregory J.
通讯作者：
Gores, Gregory J.
代谢组学揭示了猕猴自然抑郁模型中的外周和中枢短链脂肪酸和氨基酸功能障碍
影响因子：
3.2
作者：
Deng, Feng-Li;Pan, Jun-Xi;Xie, Peng
通讯作者：
Xie, Peng
DOI：
10.1111/j.1600-0773.1987.tb01712.x
发表时间：
1987-01-01
期刊：
PHARMACOLOGY & TOXICOLOGY
影响因子：
--
作者：
DYBING, E;SODERLUND, EJ;THORGEIRSSON, SS
通讯作者：
THORGEIRSSON, SS