Psychobiological mechanisms underlying the social buffering of the hypothalamic-pituitary-adrenocortical axis: a review of animal models and human studies across development.
Psychobiological mechanisms underlying the social buffering of the hypothalamic-pituitary-adrenocortical axis: a review of animal models and human studies across development.
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下丘脑 - 垂体 - 肾上腺皮质轴的社会缓冲的基础的心理生物学机制：对动物模型和人类研究的回顾。
DOI：
10.1037/a0032671
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发表时间：
2014-01
影响因子：
22.4
通讯作者：
Gunnar, Megan R.
中科院分区：
文献类型：
--
作者：
Hostinar, Camelia E.;Sullivan, Regina M.;Gunnar, Megan R.
发现社会关系的压力缓冲效应是上世纪心理生物学的主要发现之一。然而，对这种缓冲的潜在神经生物学和心理学机制的理解才刚刚开始出现。这项研究的一个重要途径涉及神经回路，可以调节下丘脑-垂体-肾上腺皮质（HPA）轴的活动。本审查是一个翻译的努力，旨在整合动物模型和人类的HPA轴从婴儿期到成年期的社会调节的研究，特别是专注于已命名的社会缓冲的过程。这一过程已注意到跨物种，并由一个阻尼HPA轴的压力反应的威胁或挑战，发生的存在或援助的同种。当存在足够的信息时，我们描述了相关的基础神经生物学的各个方面，并暴露了我们对旨在整合的文献的所有领域的理解中的主要差距。我们提供了一个工作的概念模型，集中在催产素系统和前额叶神经网络的作用，这一过程中的两个假定的生物介质，并提出，早期的经验的作用是至关重要的，在塑造后来的社会缓冲效应。这种综合指出了未来的总体方向和需要进行的具体实验，以建立一个更全面的HPA在整个生命周期中的社会缓冲效应模型，该模型包含多个层次的分析：神经内分泌、行为和社会。
Discovering the stress-buffering effects of social relationships has been one of the major findings in psychobiology in the last century. However, an understanding of the underlying neurobiological and psychological mechanisms of this buffering is only beginning to emerge. An important avenue of this research concerns the neurocircuitry that can regulate the activity of the hypothalamic-pituitary-adrenocortical (HPA) axis. The present review is a translational effort aimed at integrating animal models and human studies of the social regulation of the HPA axis from infancy to adulthood, specifically focusing on the process that has been named social buffering. This process has been noted across species and consists of a dampened HPA axis stress response to threat or challenge that occurs with the presence or assistance of a conspecific. We describe aspects of the relevant underlying neurobiology when enough information exists and expose major gaps in our understanding across all domains of the literatures we aimed to integrate. We provide a working conceptual model focused on the role of oxytocinergic systems and prefrontal neural networks as two of the putative biological mediators of this process, and propose that the role of early experiences is critical in shaping later social buffering effects. This synthesis points to both general future directions and specific experiments that need to be conducted to build a more comprehensive model of the HPA social buffering effect across the lifespan that incorporates multiple levels of analysis: neuroendocrine, behavioral, and social.
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影响因子：
34.7
作者：
Arnsten, Amy F. T.
通讯作者：
Arnsten, Amy F. T.
DOI：
10.1111/j.1469-7610.2007.01818.x
发表时间：
2008-01-01
影响因子：
7.6
作者：
Albers, Esther M.;Riksen-Walraven, J. Marianne;de Weerth, Carolina
通讯作者：
de Weerth, Carolina
影响因子：
4.8
作者：
ADAN, RAH;VANLEEUWEN, FW;BURBACH, JPH
通讯作者：
BURBACH, JPH
影响因子：
19.9
作者：
Cacioppo, John T.;Hawkey, Louise C.
通讯作者：
Hawkey, Louise C.
影响因子：
4.6
作者：
Ahnert, L;Gunnar, MR;Barthel, M
通讯作者：
Barthel, M