The Genome of the Poecilogonous Annelid Streblospio benedicti.
The Genome of the Poecilogonous Annelid Streblospio benedicti.
复制标题
DOI：
10.1093/gbe/evac008
复制
发表时间：
2022-02-04
影响因子：
3.3
通讯作者：
Rockman MV
中科院分区：
文献类型：
--
作者：
Zakas C;Harry ND;Scholl EH;Rockman MV
本尼迪克特链鞭螺是一种常见的海洋环节动物，已成为发育进化的重要模式动物。它是唯一已知的由卵大小的遗传差异引起的雌雄生殖（在一个物种中发生两种不同的发育模式）的例子。该物种的二态发育程序和生活史取决于基因组内的差异，使其成为了解发育分化的基因组基础的最佳模型。利用S.贝内迪克蒂已经开始揭示遗传学和基因组学的原则，这些原则是发育脱钩的基础，但直到现在，他们还受到缺乏基因组学工具的限制。在这里，我们提出了一个注释的染色体水平的基因组组装的S。从Illumina读段、Nanopore长读段、芝加哥和Hi-C染色质相互作用测序的组合产生的基因组序列，以及来自实验杂交的遗传图谱。在701.4Mb处，S.贝内迪克体基因组是迄今为止组装到染色体支架上的最大环节动物基因组。对S. benedicti是有价值的功能基因组分析的发展和进化，以及系统发育的比较环节动物和Lophotrochozoa。尽管有两种发育模式，但没有证据表明基因组重复或大量基因数量扩增。相反，与其他环节动物相比，谱系特异性重复序列占了该基因组扩展的大部分。
Streblospio benedicti is a common marine annelid that has become an important model for developmental evolution. It is the only known example of poecilogony (where two distinct developmental modes occur within a single species) that is due to a heritable difference in egg size. The dimorphic developmental programs and life-histories exhibited in this species depend on differences within the genome, making it an optimal model for understanding the genomic basis of developmental divergence. Studies using S. benedicti have begun to uncover the genetic and genomic principles that underlie developmental uncoupling, but until now they have been limited by the lack of availability of genomic tools. Here, we present an annotated chromosomal-level genome assembly of S. benedicti generated from a combination of Illumina reads, Nanopore long reads, Chicago and Hi-C chromatin interaction sequencing, and a genetic map from experimental crosses. At 701.4 Mb, the S. benedicti genome is the largest annelid genome to date that has been assembled to chromosomal scaffolds. The complete genome of S. benedicti is valuable for functional genomic analyses of development and evolution, as well as phylogenetic comparison within the annelida and the Lophotrochozoa. Despite having two developmental modes, there is no evidence of genome duplication or substantial gene number expansions. Instead, lineage-specific repeats account for much of the expansion of this genome compared with other annelids.
登录
查看更多内容
影响因子：
1.2
作者：
Gibson, Glenys;MacDonald, Kristen;Dufton, Megan
通讯作者：
Dufton, Megan
影响因子：
3.7
作者：
Walker BJ;Abeel T;Shea T;Priest M;Abouelliel A;Sakthikumar S;Cuomo CA;Zeng Q;Wortman J;Young SK;Earl AM
通讯作者：
Earl AM
扇贝基因组为两侧对称动物核型的进化和发育提供了见解
影响因子：
16.8
作者：
Wang, Shi;Zhang, Jinbo;Bao, Zhenmin
通讯作者：
Bao, Zhenmin
影响因子：
7.7
作者：
Zakas, Christina;Deutscher, Jennifer M.;Rockman, Matthew V.
通讯作者：
Rockman, Matthew V.
影响因子：
3.3
作者：
LEVIN, LA;ZHU, J;CREED, E
通讯作者：
CREED, E