Association of gene polymorphism of SDF1(CXCR12) with susceptibility to HIV-1 infection and AIDS disease progression: A meta-analysis.
Association of gene polymorphism of SDF1(CXCR12) with susceptibility to HIV-1 infection and AIDS disease progression: A meta-analysis.
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SDF1 (CXCR12) 基因多态性与 HIV-1 感染易感性和 AIDS 疾病进展的关联：荟萃分析
DOI：
10.1371/journal.pone.0191930
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Cen S
中科院分区：
文献类型：
--
作者：
Ding J;Zhao J;Zhou J;Li X;Wu Y;Ge M;Cen S
病毒受体的遗传多态性与HIV-1感染的风险有关，而HIV-1辅助受体CXCR 4的独特配体SDF 1的多态性是否与HIV易感性和AIDS疾病进展相关仍有争议。因此，我们通过荟萃分析对16项病例对照研究和7项队列研究进行了更新的定量评估。从PubMed、Embase和奥维德电子数据库中检索报告SDF 1多态性与HIV易感性或AIDS进展之间关系的文章，截止日期为2017年4月。采用1987年美国疾病控制中心（CDC）艾滋病病例定义（CDC 87）和1993年美国疾病控制中心（CDC）艾滋病病例定义（CDC 93）和死亡作为终点，通过HIV-1感染的比值比（OR）和95%置信区间（CI）以及艾滋病进展的汇总相对风险（RH）和95% CI合并数据。因此，荟萃分析纳入了16项关于HIV-1感染易感性的研究（2803例HIV感染患者和3697例健康个体）和7项关于疾病进展的研究（4239例受试者）。在感染风险方面，所有遗传模型均未发现SDF 1基因多态性与HIV-1感染风险相关（隐性模型：OR = 0.94，95%CI：0.75-1.17;纯合子模型：OR = 0.89，95%CI：0.70-1.15;杂合子模型：OR = 1.06，95%CI：0.83-1.35;等位基因模型：OR = 0.95，95%CI：0.79-1.13），此外，我们未能发现延迟的AIDS进展，除了在一些特定的队列中，包括MACS队列（研究入组时至AIDS的时间RH = 0.38，95%CI：0.17-0.59;至死亡的时间RH = 0.27，95%CI：0.07-0.46）。总体而言，SDF 1基因多态性与HIV易感性之间无显著相关性。特别是在基于相同队列的两项研究中，观察到SDF 1对艾滋病进展和死亡的保护作用。总之，SDF 1多态性在某些特定人群中对艾滋病病情恶化具有中度保护作用。
Genetic polymorphism of viral receptors is relevant to risks of HIV-1 infection, while it is still under debated whether the polymorphism of SDF1, a unique ligand for HIV-1 coreceptor CXCR4, is associated with HIV susceptibility and AIDS disease progression. Therefore, we provided an updated quantitative assessment by meta-analysis from 16 case-control and 7 cohort studies. Articles reporting the relationship between SDF1 polymorphism and HIV susceptibility or AIDS progression were retrieved from PubMed, Embase and Ovid electronic databases up to Apr 2017. Data were pooled by odds ratios (ORs) for HIV-1 infection with 95% confidence intervals (CIs) and summary relative hazards (RHs) for AIDS progression with 95% CIs using 1987 Center for Disease Control (CDC) case definition of AIDS (CDC87) and 1993 Center for Disease Control (CDC) case definition of AIDS (CDC93) and death as endpoints. As a result, 16 studies regarding susceptibility to HIV-1 infection with 2803 HIV-infected patients and 3697 healthy individuals and 7 studies regarding disease progression with 4239 subjects were included in the meta-analysis. For risks of infection, no evidences indicated SDF1 polymorphism was associated with the risk of HIV-1 infection in all genetic models (recessive model: OR = 0.94, 95% Cl: 0.75–1.17; homozygous model: OR = 0.89, 95% Cl: 0.70–1.15; heterozygous model: OR = 1.06, 95% Cl: 0.83–1.35; allele model: OR = 0.95, 95% Cl: 0.79–1.13), Furthermore, we failed to find an delayed AIDS progression except in some specific cohorts including MACS cohorts (RH = 0.38, 95% Cl: 0.17–0.59 for time to AIDS; RH = 0.27, 95% Cl: 0.07–0.46 for time to death at the study entry). Overall, no significant association was found between SDF1 polymorphism and HIV susceptibility. A protective effect of SDF1 on AIDS progression and death was seen especially in two studies based on the same cohorts. In conclusion, SDF1 polymorphism exerts a moderate protective effect against AIDS disease deterioration in some specific populations.
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影响因子：
6.4
作者：
Brambilla, A;Villa, C;Vicenzi, E
通讯作者：
Vicenzi, E
影响因子：
15.8
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
DOI：
10.1097/01.qai.0000157008.66584.d6
发表时间：
2005-09-01
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作者：
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