Extracellular Matrix Stiffness in Lung Health and Disease.
Extracellular Matrix Stiffness in Lung Health and Disease.
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肺部健康和疾病中的细胞外基质刚度。
DOI：
10.1002/cphy.c210032
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发表时间：
2022-06-29
影响因子：
5.8
通讯作者：
Zhou, Yong
中科院分区：
文献类型：
--
作者：
Guo, Ting;He, Chao;Venado, Aida;Zhou, Yong
细胞外基质（ECM）提供结构支持，并赋予细胞各种各样的环境线索。在过去的十年中，越来越多的工作表明，ECM的机械特性，通常称为基质刚度，调节肺的基本细胞过程。越来越多的人认识到，细胞和相关ECM之间的机械相互作用对于维持肺内稳态是必不可少的。ECM衍生的机械信号通过改变机械传感和机械转导途径的失调与许多常见的肺部疾病有关。基质硬化是肺纤维化的标志。硬化的ECM不仅是肺纤维化的后遗症，而且可以积极推动纤维化肺病的进展。在这篇文章中，我们提供了一个全面的看法，在肺健康和疾病的基质硬度的作用。我们开始通过总结基质硬度对各种肺细胞类型的功能和行为以及对生物分子活性和关键生理过程（包括宿主免疫应答和细胞代谢）的调节的影响。我们讨论了潜在的机制，细胞探针矩阵刚度和转换机械信号来调节基因表达。我们强调了控制基质硬度的因素，并概述了基质硬度在肺发育中的作用以及肺纤维化、肺动脉高压、哮喘、慢性阻塞性肺疾病（COPD）和肺癌的发病机制。我们设想靶向有害的基质机械线索治疗纤维化肺疾病。矩阵刚度测量和刚度可调矩阵基板的设计技术的进展也进行了探讨。
The extracellular matrix (ECM) provides structural support and imparts a wide variety of environmental cues to cells. In the past decade, a growing body of work revealed that the mechanical properties of the ECM, commonly known as matrix stiffness, regulate the fundamental cellular processes of the lung. There is growing appreciation that mechanical interplays between cells and associated ECM are essential to maintain lung homeostasis. Dysregulation of ECM-derived mechanical signaling via altered mechanosensing and mechanotransduction pathways is associated with many common lung diseases. Matrix stiffening is a hallmark of lung fibrosis. The stiffened ECM is not merely a sequelae of lung fibrosis but can actively drive the progression of fibrotic lung disease. In this article, we provide a comprehensive view on the role of matrix stiffness in lung health and disease. We begin by summarizing the effects of matrix stiffness on the function and behavior of various lung cell types and on regulation of biomolecule activity and key physiological processes, including host immune response and cellular metabolism. We discuss the potential mechanisms by which cells probe matrix stiffness and convert mechanical signals to regulate gene expression. We highlight the factors that govern matrix stiffness and outline the role of matrix stiffness in lung development and the pathogenesis of pulmonary fibrosis, pulmonary hypertension, asthma, chronic obstructive pulmonary disease (COPD), and lung cancer. We envision targeting of deleterious matrix mechanical cues for treatment of fibrotic lung disease. Advances in technologies for matrix stiffness measurements and design of stiffness-tunable matrix substrates are also explored.
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影响因子：
14
作者：
Wood, Joshua A.;Shah, Nihar M.;McKee, Clayton T.;Hughbanks, Marissa L.;Liliensiek, Sara J.;Russell, Paul;Murphy, Christopher J.
通讯作者：
Murphy, Christopher J.
影响因子：
64.8
作者：
Barriga EH;Franze K;Charras G;Mayor R
通讯作者：
Mayor R
影响因子：
4.6
作者：
Aumiller V;Strobel B;Romeike M;Schuler M;Stierstorfer BE;Kreuz S
通讯作者：
Kreuz S
影响因子：
3.4
作者：
Alcaraz, J;Buscemi, L;Navajas, D
通讯作者：
Navajas, D
DOI：
10.1016/0925-4439(95)00069-g
发表时间：
1995-08-15
影响因子：
6.2
作者：
BELLMUNT, MJ;PORTERO, M;PRAT, J
通讯作者：
PRAT, J