Neural mechanisms of high-risk decisions-to-drink in alcohol-dependent women.
Neural mechanisms of high-risk decisions-to-drink in alcohol-dependent women.
复制标题
DOI：
10.1111/adb.12121
复制
发表时间：
2015-03
影响因子：
3.4
通讯作者：
James TW
中科院分区：
文献类型：
--
作者：
Arcurio LR;Finn PR;James TW
酒精依赖（AD）的一个标志是继续饮酒，尽管有负面后果的风险。目前，尚不清楚AD中的无序激活模式是否与过度敏感的奖励系统、控制系统的缺陷或两者的组合更相容，以产生AD中观察到的高风险行为。在这里，酒精线索被用于一个生态决策饮酒任务，涉及高风险和低风险的情况下，严重的负面想象后果的机会是不同的。非酒精线索作为控制刺激。使用fMRI测量15名AD和16名对照妇女的BOLD信号变化。这个设计使我们能够解决关于酒精依赖的两个主要问题：第一，是否存在一种特定的无序激活模式，这种模式促使广告中高风险饮酒决策的高度认可？第二，这种模式是特定于饮酒的决定，还是普遍适用于其他食欲和/或中性线索？结果表明，在高风险的决定，以喝，AD妇女激活奖励电路，认知控制电路，和区域的默认模式网络（DMN），而控制妇女停用的方法电路，并显示增强激活区域的DMN。组间差异只在饮酒决定上存在，这表明它们是特定于酒精的暗示。同时激活的奖励网络，认知控制网络，和DMN在AD妇女表明，过度认可的高风险饮酒的决定，AD妇女可能是由于不同的神经网络之间的切换问题。
A hallmark of alcohol dependence (AD) is continuing to drink despite the risk of negative consequences. Currently, it is not known if the pattern of disordered activation in AD is more compatible with an over-sensitive reward system, a deficit in control systems, or a combination of both to produce the high risk-taking behavior observed in ADs. Here, alcohol cues were used in an ecological decisions-to-drink task that involved high- and low-risk scenarios where the chance of serious negative imagined consequences was varied. Non-alcohol cues were included as control stimuli. fMRI was used to measure BOLD signal change in 15 AD and 16 control women. This design allowed us to address two major questions concerning alcohol dependence: first, is there a specific pattern of disordered activation that drives the heightened endorsement of high-risk decisions-to-drink in ADs? And, second, is that pattern specific to decisions-to-drink or does it generalize to other appetitive and/or neutral cues? The results showed that, during high-risk decisions-to-drink, AD women activated reward circuits, cognitive control circuits, and regions of the default-mode network (DMN), while control women deactivated approach circuits and showed enhanced activation in regions of the DMN. Group differences were found only for decisions-to-drink, suggesting that they are specific to alcohol cues. Simultaneous activation of reward networks, cognitive control networks, and the DMN in AD women suggests that over-endorsement of high-risk drinking decisions by AD women may be due to a problem with switching between different neural networks.
登录
查看更多内容
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
3.6
作者：
Crews, Fulton Timm;Boettiger, Charlotte Ann
通讯作者：
Boettiger, Charlotte Ann
影响因子：
3.7
作者：
Ihssen, Niklas;Cox, W. Miles;Linden, David E. J.
通讯作者：
Linden, David E. J.
影响因子：
3.4
作者：
Bogg, Tim;Finn, Peter R.
通讯作者：
Finn, Peter R.
DOI：
10.1177/1534582302001003001
发表时间：
2002-09-01
期刊：
Behavioral and cognitive neuroscience reviews
影响因子：
--
作者：
Finn, Peter R
通讯作者：
Finn, Peter R