Quantitative Analysis of Synthetic Magnetic Resonance Imaging in Alzheimer's Disease.
Quantitative Analysis of Synthetic Magnetic Resonance Imaging in Alzheimer's Disease.
复制标题
阿尔茨海默病的合成磁共振成像定量分析
DOI：
10.3389/fnagi.2021.638731
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发表时间：
2021
影响因子：
4.8
通讯作者：
Chen M
中科院分区：
文献类型：
--
作者：
Lou B;Jiang Y;Li C;Wu PY;Li S;Qin B;Chen H;Wang R;Wu B;Chen M
目的：本研究的目的是评估合成 MRI 的可行性以及是否有助于诊断阿尔茨海默病 (AD)。材料和方法：18 名患者和 18 名年龄匹配的正常对照 (NC) 接受了 MR 检查。所有患者均获得简易精神状态检查（MMSE）评分。获得不同皮质和皮质下区域的全脑体积特征、T1、T2和质子密度（PD）值。使用独立样本 t 检验比较 AD 患者和 NC 患者之间的体积特征和脑区域松弛值。这些定量参数与 MMSE 评分之间的相关性通过 AD 患者的 Pearson 相关性进行评估。结果：虽然AD患者的脑脊液量（CSF）较多，脑实质体积（BPV）较低，脑实质体积与颅内体积之比（BPV/ICV）较NC患者较低，但差异无统计学意义（p > 0.05）。 AD患者右侧岛叶皮质T1值以及左侧海马和右侧岛叶皮质T2值均显着高于NC患者，但左侧尾状核T1值则呈现相反趋势（p < 0.05）。随着AD患者MMSE评分降低，BPV和BPV/ICV降低，而CSF体积、双侧岛叶皮质和双侧海马的T1值以及双侧海马的T2值增加（p < 0.05）。结论：综合MRI不仅可以提供更多的信息来区分AD患者与正常对照，而且可以反映AD疾病的严重程度。
Objectives: The purpose of this study was to evaluate the feasibility and whether synthetic MRI can benefit diagnosis of Alzheimer’s disease (AD). Materials and Methods: Eighteen patients and eighteen age-matched normal controls (NCs) underwent MR examination. The mini-mental state examination (MMSE) scores were obtained from all patients. The whole brain volumetric characteristics, T1, T2, and proton density (PD) values of different cortical and subcortical regions were obtained. The volumetric characteristics and brain regional relaxation values between AD patients and NCs were compared using independent-samples t-test. The correlations between these quantitative parameters and MMSE score were assessed by the Pearson correlation in AD patients. Results: Although the larger volume of cerebrospinal fluid (CSF), lower brain parenchymal volume (BPV), and the ratio of brain parenchymal volume to intracranial volume (BPV/ICV) were found in AD patients compared with NCs, there were no significant differences (p > 0.05). T1 values of right insula cortex and T2 values of left hippocampus and right insula cortex were significantly higher in AD patients than in NCs, but T1 values of left caudate showed a reverse trend (p < 0.05). As the MMSE score decreased in AD patients, the BPV and BPV/ICV decreased, while the volume of CSF and T1 values of bilateral insula cortex and bilateral hippocampus as well as T2 values of bilateral hippocampus increased (p < 0.05). Conclusion: Synthetic MRI not only provides more information to differentiate AD patients from normal controls, but also reflects the disease severity of AD.
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DOI：
10.1016/j.nicl.2017.04.001
发表时间：
2017
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Ramos Bernardes da Silva Filho S;Oliveira Barbosa JH;Rondinoni C;Dos Santos AC;Garrido Salmon CE;da Costa Lima NK;Ferriolli E;Moriguti JC
通讯作者：
Moriguti JC
影响因子：
14
作者：
通讯作者：
--
影响因子：
4.2
作者：
Callaghan MF;Freund P;Draganski B;Anderson E;Cappelletti M;Chowdhury R;Diedrichsen J;Fitzgerald TH;Smittenaar P;Helms G;Lutti A;Weiskopf N
通讯作者：
Weiskopf N
影响因子：
9.9
作者：
ARRIAGADA, PV;GROWDON, JH;HYMAN, BT
通讯作者：
HYMAN, BT
影响因子：
5.9
作者：
Gracien, Rene-Maxime;Reitz, Sarah C.;Klein, Johannes C.
通讯作者：
Klein, Johannes C.