Widespread age-related differences in the human brain microstructure revealed by quantitative magnetic resonance imaging.
Widespread age-related differences in the human brain microstructure revealed by quantitative magnetic resonance imaging.
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DOI：
10.1016/j.neurobiolaging.2014.02.008
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发表时间：
2014-08
影响因子：
4.2
通讯作者：
Weiskopf N
中科院分区：
文献类型：
--
作者：
Callaghan MF;Freund P;Draganski B;Anderson E;Cappelletti M;Chowdhury R;Diedrichsen J;Fitzgerald TH;Smittenaar P;Helms G;Lutti A;Weiskopf N
迫切需要将与年龄相关的变化与病理性神经变性区分开来。本研究旨在描述正常衰老过程中体内生物学相关指标的空间格局和年龄相关差异。从138名健康志愿者（年龄范围：19-75岁）中获得定量多参数图，提供髓鞘形成和铁水平的神经成像生物标志物，这些参数对衰老敏感。全脑体素分析揭示了年龄相关退化的全球模式。显著的脱髓鞘主要发生在白质。观察到的与年龄相关的髓鞘形成差异具有解剖学特异性。与浸润性组织学报告一致，胼胝体膝的年龄相关差异高于脾。铁水平在基底神经节、红核和广泛皮质区显著升高，但在枕额上束和视神经辐射区下降。这种无症状人群中与年龄相关的微结构差异的全脑模式为衰老的神经生物学提供了见解。这些结果有助于建立一个定量的基线，以此来检查和划分健康衰老和病理性神经变性之间的分界线。
A pressing need exists to disentangle age-related changes from pathologic neurodegeneration. This study aims to characterize the spatial pattern and age-related differences of biologically relevant measures in vivo over the course of normal aging. Quantitative multiparameter maps that provide neuroimaging biomarkers for myelination and iron levels, parameters sensitive to aging, were acquired from 138 healthy volunteers (age range: 19–75 years). Whole-brain voxel-wise analysis revealed a global pattern of age-related degeneration. Significant demyelination occurred principally in the white matter. The observed age-related differences in myelination were anatomically specific. In line with invasive histologic reports, higher age-related differences were seen in the genu of the corpus callosum than the splenium. Iron levels were significantly increased in the basal ganglia, red nucleus, and extensive cortical regions but decreased along the superior occipitofrontal fascicle and optic radiation. This whole-brain pattern of age-associated microstructural differences in the asymptomatic population provides insight into the neurobiology of aging. The results help build a quantitative baseline from which to examine and draw a dividing line between healthy aging and pathologic neurodegeneration.
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影响因子：
4.4
作者：
Helms, Gunther;Dechent, Peter
通讯作者：
Dechent, Peter
影响因子：
4.2
作者：
CONNOR, JR;MENZIES, SL;MUFSON, EJ
通讯作者：
MUFSON, EJ
影响因子：
3.3
作者：
Deoni, SCL;Peters, TM;Rutt, BK
通讯作者：
Rutt, BK
影响因子：
4.2
作者：
Bartzokis G
通讯作者：
Bartzokis G
影响因子：
38.1
作者：
Frisoni, Giovanni B.;Fox, Nick C.;Jack, Clifford R., Jr.;Scheltens, Philip;Thompson, Paul M.
通讯作者：
Thompson, Paul M.