Roles of Macrophages in Atherogenesis.
Roles of Macrophages in Atherogenesis.
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DOI：
10.3389/fphar.2021.785220
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发表时间：
2021
影响因子：
5.6
通讯作者：
Lusis AJ
中科院分区：
文献类型：
--
作者：
Farahi L;Sinha SK;Lusis AJ
动脉粥样硬化是一种慢性炎症性疾病，最终可能导致局部蛋白水解、斑块破裂和血栓性血管疾病，导致心肌梗塞、中风和心源性猝死。循环单核细胞响应炎症损伤而被募集到动脉壁并分化为巨噬细胞，巨噬细胞对组织损伤、伤口愈合以及动脉粥样硬化病变的消退做出了重要贡献。在斑块内，巨噬细胞吸收进入血管壁的聚集脂蛋白，产生充满胆固醇的泡沫细胞。此外，巨噬细胞表型受到各种刺激的影响，这些刺激影响其极化、胞吞作用、增殖和凋亡。最近通过单细胞测序技术解决了病变中巨噬细胞的异质性。本文回顾了巨噬细胞在从动脉粥样硬化起始到晚期的疾病发病机制不同阶段中的作用的最新进展。还描述了用于动脉粥样硬化管理的基于巨噬细胞的疗法。
Atherosclerosis is a chronic inflammatory disease that may ultimately lead to local proteolysis, plaque rupture, and thrombotic vascular disease, resulting in myocardial infarction, stroke, and sudden cardiac death. Circulating monocytes are recruited to the arterial wall in response to inflammatory insults and differentiate into macrophages which make a critical contribution to tissue damage, wound healing, and also regression of atherosclerotic lesions. Within plaques, macrophages take up aggregated lipoproteins which have entered the vessel wall to give rise to cholesterol-engorged foam cells. Also, the macrophage phenotype is influenced by various stimuli which affect their polarization, efferocytosis, proliferation, and apoptosis. The heterogeneity of macrophages in lesions has recently been addressed by single-cell sequencing techniques. This article reviews recent advances regarding the roles of macrophages in different stages of disease pathogenesis from initiation to advanced atherosclerosis. Macrophage-based therapies for atherosclerosis management are also described.
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