Antimicrobial Resistance and Its Spread Is a Global Threat.
Antimicrobial Resistance and Its Spread Is a Global Threat.
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DOI：
10.3390/antibiotics11081082
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发表时间：
2022-08-09
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影响因子：
--
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中科院分区：
文献类型：
--
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抗微生物药物耐药性（AMR）是全球人类福祉面临的一项挑战，也是较为严重的公共卫生问题之一。如果不加以控制，AMR有可能成为严重的医疗保健威胁，并可能引发另一场大流行。这就确立了围绕AMR制定全球卫生解决方案的必要性，同时要考虑到来自世界不同地区的微观数据。在这方面的积极影响可能包括建立有利的社会规范，制定有利于全球人类健康的个人和群体行为准则，以及最后提高对采取此类行动的必要性的集体意识。除了在临床领域是一种新兴威胁外，AMR还增加了治疗的复杂性，对现有的抗生素耐药性管理指南构成了真正的挑战。耐药性发展的特性与许多基因要素有关，其中一些在微生物之间具有复杂的传播途径。除此之外，正在发现AMR发展的新机制，这使得该领域成为医学微生物学的一个重要方面。除了AMR的基因方面，其他行为，包括误诊、接触广谱抗生素以及缺乏快速诊断，都加剧了耐药性的产生。然而，DNA测序技术与生物信息学的升级和创新已经给诊断行业带来了革命性的变化，有助于实时检测AMR的病因及其要素，这对于制定控制和预防方法以应对这一威胁至关重要。
Antimicrobial resistance (AMR) is a challenge to human wellbeing the world over and is one of the more serious public health concerns. AMR has the potential to emerge as a serious healthcare threat if left unchecked, and could put into motion another pandemic. This establishes the need for the establishment of global health solutions around AMR, taking into account microdata from different parts of the world. The positive influences in this regard could be establishing conducive social norms, charting individual and group behavior practices that favor global human health, and lastly, increasing collective awareness around the need for such action. Apart from being an emerging threat in the clinical space, AMR also increases treatment complexity, posing a real challenge to the existing guidelines around the management of antibiotic resistance. The attribute of resistance development has been linked to many genetic elements, some of which have complex transmission pathways between microbes. Beyond this, new mechanisms underlying the development of AMR are being discovered, making this field an important aspect of medical microbiology. Apart from the genetic aspects of AMR, other practices, including misdiagnosis, exposure to broad-spectrum antibiotics, and lack of rapid diagnosis, add to the creation of resistance. However, upgrades and innovations in DNA sequencing technologies with bioinformatics have revolutionized the diagnostic industry, aiding the real-time detection of causes of AMR and its elements, which are important to delineating control and prevention approaches to fight the threat.
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影响因子：
2.8
作者：
Karp BE;Tate H;Plumblee JR;Dessai U;Whichard JM;Thacker EL;Hale KR;Wilson W;Friedman CR;Griffin PM;McDermott PF
通讯作者：
McDermott PF
影响因子：
9.4
作者：
Gordon NC;Price JR;Cole K;Everitt R;Morgan M;Finney J;Kearns AM;Pichon B;Young B;Wilson DJ;Llewelyn MJ;Paul J;Peto TE;Crook DW;Walker AS;Golubchik T
通讯作者：
Golubchik T
影响因子：
4.9
作者：
Dally, Simon;Lemuth, Karin;Weile, Jan
通讯作者：
Weile, Jan
影响因子：
3.7
作者：
Castro-Sánchez E;Moore LS;Husson F;Holmes AH
通讯作者：
Holmes AH
DOI：
10.1073/pnas.1016217108
发表时间：
2011-04-19
影响因子：
11.1
作者：
Hassaninasab, Azam;Hashimoto, Yoshiteru;Kobayashi, Michihiko
通讯作者：
Kobayashi, Michihiko