A Compartmentalized Out-of-Equilibrium Enzymatic Reaction Network for Sustained Autonomous Movement.
A Compartmentalized Out-of-Equilibrium Enzymatic Reaction Network for Sustained Autonomous Movement.
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DOI：
10.1021/acscentsci.6b00254
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发表时间：
2016-11-23
影响因子：
18.2
通讯作者：
van Hest, Jan C. M.
中科院分区：
文献类型：
--
作者：
Nijemeisland, Marlies;Abdelmohsen, Loai K. E. A.;Huck, Wilhelm T. S.;Wilson, Daniela A.;van Hest, Jan C. M.
每个活着的细胞都是一个分隔的、不平衡的系统，能够巧妙地将化学能转化为功能。为了维持动态平衡，代谢产物的流量受到调控酶网络的严格控制。开发栩栩如生的材料的一个关键前提是构建具有分隔的反应网络的合成系统，以保持非平衡功能。在这里，我们的目标是自主运动，作为原料分子转化为功能的一个例子。转化的通量由合理设计的具有多个前馈回路的酶反应网络来调节。通过将网络划分为碗形纳米胶囊，网络的输出被收集为动能。由于多个外部基质的转换，整个系统显示出持续和可调的微观运动。对非平衡反应网络的成功划分是利用生命的设计原则构建适应性和内部调节的逼真系统的重要第一步。将酶网络封装在碗形胶囊中，形成了能够在广泛的燃料浓度范围内显示持续和可调节运动的纳米马达。
Every living cell is a compartmentalized out-of-equilibrium system exquisitely able to convert chemical energy into function. In order to maintain homeostasis, the flux of metabolites is tightly controlled by regulatory enzymatic networks. A crucial prerequisite for the development of lifelike materials is the construction of synthetic systems with compartmentalized reaction networks that maintain out-of-equilibrium function. Here, we aim for autonomous movement as an example of the conversion of feedstock molecules into function. The flux of the conversion is regulated by a rationally designed enzymatic reaction network with multiple feedforward loops. By compartmentalizing the network into bowl-shaped nanocapsules the output of the network is harvested as kinetic energy. The entire system shows sustained and tunable microscopic motion resulting from the conversion of multiple external substrates. The successful compartmentalization of an out-of-equilibrium reaction network is a major first step in harnessing the design principles of life for construction of adaptive and internally regulated lifelike systems. The encapsulation of an enzymatic network in a bowl-shaped capsule results in a nanomotor that is able to demonstrate sustained and regulated motion in a wide concentration range of fuel.
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影响因子：
17.1
作者：
Ma X;Jang S;Popescu MN;Uspal WE;Miguel-López A;Hahn K;Kim DP;Sánchez S
通讯作者：
Sánchez S
影响因子：
2.9
作者：
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通讯作者：
Showalter, Kenneth
DOI：
10.1073/pnas.0603873103
发表时间：
2006-12-26
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
56.9
作者：
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通讯作者：
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影响因子：
17.1
作者：
Ma, Xing;Wang, Xu;Sanchez, Samuel
通讯作者：
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