A quantitative test of the neutral theory using pooled allozyme data.
A quantitative test of the neutral theory using pooled allozyme data.
复制标题
使用汇总的等位酶数据对中性理论进行定量检验。
作者：
D. Skibinski;M. Woodwark;R. Ward
中性理论预测物种内的多态性数量与进化速率之间存在正相关关系。以前的测试，这种预测使用等位酶和DNA数据导致了相互矛盾的结论选择和突变漂移的影响。这里有人认为，中性理论的充分性的定量结论可以通过分析从许多来源汇集的遗传数据。使用这种方法，一个大型的数据库，包含超过1500个物种的等位酶变异的信息被用来研究杂合性和遗传距离之间的关系。研究结果支持了这一假设，即蛋白质变异的主要百分比可以解释为中性突变率的变化，和一个小的百分比强选择。
Neutral theory predicts a positive correlation between the amount of polymorphism within species and evolutionary rate. Previous tests of this prediction using both allozyme and DNA data have led to conflicting conclusions about the influence of selection and mutation drift. It is argued here that quantitative conclusions about the adequacy of neutral theory can be obtained by analyzing genetic data pooled from many sources. Using this approach, a large database containing information on allozyme variation in over 1500 species is used to examine the relationship between heterozygosity and genetic distance. The results provide support for the hypothesis that a major percentage of protein variation can be explained by variation in neutral mutation rate, and a minor percentage by strong selection.
影响因子：
3.3
作者：
M. Kreitman;R. Hudson
通讯作者：
M. Kreitman;R. Hudson
影响因子：
2.5
作者：
Rabie, TSKM;Crooijmans, RPMA;Groenen, MAM
通讯作者：
Groenen, MAM
果蝇 X 染色体远端部分的分子群体遗传学：黄果树区域遗传搭便车的证据。
影响因子：
3.3
作者：
Begun,DJ;Aquadro,CF
通讯作者：
Aquadro,CF