Environmental enrichment rescues binocular matching of orientation preference in mice that have a precocious critical period.
Environmental enrichment rescues binocular matching of orientation preference in mice that have a precocious critical period.
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DOI：
10.1016/j.neuron.2013.07.023
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发表时间：
2013-10-02
期刊：
影响因子：
16.2
通讯作者：
Cang J
中科院分区：
文献类型：
--
作者：
Wang BS;Feng L;Liu M;Liu X;Cang J
在生命早期的关键时期，经验塑造了神经回路。关键时期的时间由遗传和环境调节。在这里，我们研究的功能意义，这种时间的规定，在小鼠初级视觉皮层，关键期可塑性驱动双眼匹配的方向偏好。我们发现，由于基因增强抑制，具有早熟关键期的小鼠的双眼匹配被永久破坏。这种破坏是一种类型的神经元所特有的，复杂细胞，正如我们所揭示的那样，通常在简单细胞之后匹配。早期的环境富集通过诱导组蛋白乙酰化，从而推进匹配过程以与早熟的可塑性相一致，从而完全挽救了缺陷。因此，我们的实验表明，适当的时机的关键时期是必不可少的建立正常的双眼和有害的影响，其遗传失调，可以改善环境操纵通过表观遗传机制。
Experience shapes neural circuits during critical periods in early life. The timing of critical periods is regulated by both genetics and the environment. Here we study the functional significance of such temporal regulations in the mouse primary visual cortex, where critical period plasticity drives binocular matching of orientation preference. We find that the binocular matching is permanently disrupted in mice that have a precocious critical period due to genetically enhanced inhibition. The disruption is specific to one type of neurons, the complex cells, which, as we reveal, normally match after the simple cells. Early environmental enrichment completely rescues the deficit by inducing histone acetylation and consequently advancing the matching process to coincide with the precocious plasticity. Our experiments thus demonstrate that the proper timing of the critical period is essential for establishing normal binocularity and the detrimental impact of its genetic misregulation can be ameliorated by environmental manipulations via epigenetic mechanisms.
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