High urinary excretion rate of glucose attenuates serum uric acid level in type 2 diabetes with normal renal function.
High urinary excretion rate of glucose attenuates serum uric acid level in type 2 diabetes with normal renal function.
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肾功能正常的 2 型糖尿病患者的高尿葡萄糖排泄率降低了血清尿酸水平
DOI：
10.1007/s40618-021-01513-8
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发表时间：
2021-09
影响因子：
5.4
通讯作者：
Chang B
中科院分区：
文献类型：
--
作者：
Qin Y;Zhang S;Cui S;Shen X;Wang J;Cui X;Zuo M;Gao Z;Zhang J;Yang J;Zhu H;Chang B
2型糖尿病（T2D）成人患者的尿糖排泄率（UEGL）与尿酸（UA）代谢之间的关系至今仍不明确。本研究旨在探讨2型糖尿病成人患者的UEGL与血清尿酸（SUA）、尿酸尿排泄率（UEUA）以及尿酸肾清除率（CLUA）之间的关系。我们假设高UEGL会增加尿酸排泄，进而导致SUA降低。
这是一项对2018年至2019年期间招募的635名2型糖尿病住院患者进行的横断面研究。采用协方差分析和多元回归分析评估了UEGL与UEUA、CLUA以及高尿酸血症之间的关系。
UEGL处于较高四分位数的患者往往比处于较低四分位数的患者具有更低的SUA水平。相反，UEGL处于较高四分位数的患者往往具有更高的CLUA（趋势P＜0.0001），并且UEUA也观察到了类似的趋势。在调整后的多变量线性回归模型中，UEGL与SUA呈负相关（β = -0.023，95%置信区间 -0.034至 -0.013，P＜0.0001）。然而，发现UEGL与UEUA（β = 0.046，95%置信区间0.018 - 0.074，P = 0.001）以及CLUA（β = 0.063，95%置信区间0.042 - 0.085，P＜0.0001）呈正相关。此外，在调整后的多元逻辑回归模型中，观察到UEGL的四分位数与高尿酸血症之间存在一致的显著负相关。
高UEGL水平与UEUA和CLUA呈正相关。此外，它与SUA水平呈负相关，并且UEGL水平持续升高可降低2型糖尿病患者患高尿酸血症的风险。
The relationship between urinary excretion rate of glucose (UEGL) and uric acid (UA) metabolism in adults with type 2 diabetes (T2D) remains unclear to date. This study aimed to investigate the relationships of UEGL with serum UA (SUA), urinary excretion rate of uric acid (UEUA), and renal clearance of uric acid (CLUA) in adults with T2D. We hypothesised that high UEGL increases UA excretion, which in turn leads to lower SUA. This was a cross-sectional study of 635 inpatients with T2D recruited between 2018 and 2019. The relationships of UEGL with UEUA, CLUA, and hyperuricaemia were assessed using analysis of covariance and multivariate regression analysis. Patients in the higher quartile of UEGL tended to have lower SUA levels than those in the lower quartile. In contrast, patients in the higher quartile of UEGL tended to have higher CLUA (p for trend < 0.0001), and a similar trend was observed for UEUA. In adjusted multivariable linear regression model, UEGL was negatively correlated with SUA (β = − 0.023, 95% CI − 0.034 to − 0.013, p < 0.0001). However, positive correlations of UEGL with UEUA (β = 0.046, 95% CI 0.018–0.074, p = 0.001) and CLUA (β = 0.063, 95% CI 0.042–0.085, p < 0.0001) were found. Furthermore, consistent significant inverse associations were observed between quartiles of UEGL and hyperuricaemia in the adjusted multivariate logistic regression model. A high UEGL level was positively correlated with UEUA and CLUA. Moreover, it was inversely associated with SUA level, and a consistently increased UEGL level reduced the risk of hyperuricaemia in patients with T2D.
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影响因子：
10.7
作者：
Sharaf El Din UAA;Salem MM;Abdulazim DO
通讯作者：
Abdulazim DO
DOI：
10.1152/ajprenal.00555.2014
发表时间：
2015-01-15
影响因子：
4.2
作者：
Lytvyn, Yuliya;Skrtic, Marko;Cherney, David Z. I.
通讯作者：
Cherney, David Z. I.
影响因子：
120.7
作者：
Fang, J;Alderman, MH
通讯作者：
Alderman, MH
影响因子：
4.8
作者：
Anzai, Naohiko;Ichida, Kimiyoshi;Sakurai, Hiroyuki
通讯作者：
Sakurai, Hiroyuki
影响因子：
2.2
作者：
GonzalezSilicia, L;GarciaEstan, J;Hernandez, J
通讯作者：
Hernandez, J