Improvement in sampling and modulation of multiplexing with temporal shuttering of adaptable apertures in a brain-dedicated multi-pinhole SPECT system.
Improvement in sampling and modulation of multiplexing with temporal shuttering of adaptable apertures in a brain-dedicated multi-pinhole SPECT system.
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通过在脑使用的多针孔SPECT系统中的适应性孔的时间快门，改善多路复用的采样和调制。
DOI：
10.1088/1361-6560/abd5cd
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发表时间：
2021-03-02
影响因子：
3.5
通讯作者：
中科院分区：
文献类型：
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作者：
我们正在开发一种多探测器针孔固定脑专用SPECT系统：AdaptiSPECT-C。在这项工作中，我们引入了一个新的设计原型，每个探测器具有多个自适应针孔孔径，通过使用孔径的时间掩模来调制多路复用。孔径在扫描时间内的时间快门为AdaptiSPECT-C提供了多帧采集的能力。通过分析模拟，我们研究了投影复用对图像质量的影响，使用了几个数字幻影和一个定制的模拟脑灌注临床分布的拟人化幻影。该系统准直器的105个针孔分为中心孔、轴向孔和侧向孔。通过仿真，我们生成了不同复用级别的准直器。通过改变采集帧的成像时间份额，创建了几种数据采集方案。与AdaptiSPECT-C的单针孔探测器基本配置相比，当在高复用场景下使用具有相同采集时间份额的三帧方案中使用中心、轴向和侧向孔径时，灵敏度提高了35%。通过增加轴向和侧向孔径，增强了基底结构的轴向和角向采样。我们证明了可以利用孔径的时间掩模，以交换灵敏度，来调制MUX并获得一组非多路复用非截断投影。我们的研究结果表明，重建受益于利用非复用投影和调制复用投影，从而显著减少复用引起的图像伪影。与Defrise（热棒）假体研究的基本配置相比，当中心孔和轴孔（侧孔）具有相同的时间份额时，对比恢复系数提高了20%（9%）。结果表明，在每个模拟多路复用水平上，脑灰质区域的归一化均方根误差在联合使用中央孔和轴/侧孔时达到最低。
We are developing a multi-detector pinhole-based stationary brain-dedicated SPECT system: AdaptiSPECT-C. In this work, we introduced a new design prototype with multiple adaptable pinhole apertures for each detector to modulate the multiplexing by employing temporal shuttering of apertures. Temporal shuttering of apertures over the scan time provides the AdaptiSPECT-C with the capability of multiple-frame acquisition. We investigated, through analytic simulation, the impact of projection multiplexing on image quality using several digital phantoms and a customized anthropomorphic phantom emulating brain perfusion clinical distribution. The 105 pinholes in the collimator of the system were categorized into central, axial, and lateral apertures. We generated, through simulation, collimators of different multiplexing levels. Several data acquisition schemes were also created by changing the imaging time share of the acquisition frames. Sensitivity increased by 35% compared to the single-pinhole-per-detector base configuration of the AdaptiSPECT-C when using the central, axial, and lateral apertures with equal acquisition time shares within a triple-frame scheme with a high multiplexing scenario. Axial and angular sampling of the base configuration was enhanced by adding the axial and lateral apertures. We showed that the temporal shuttering of apertures can be exploited, trading the sensitivity, to modulate the MUX and to acquire a set of non-multiplexed non-truncated projections. Our results suggested that reconstruction benefited from utilizing both non-multiplexed projections and projections with modulated multiplexing resulting in a noticeably reduction in the multiplexing-induced image artefacts. Contrast recovery factor improved by 20% (9%) compared to the base configuration for a Defrise (hot-rod) phantom study when the central and axial (lateral) apertures with equal time shares were combined. The results revealed that, as an overall trend at each simulated multiplexing level, lowest normalized root-mean-square errors for the brain gray-matter regions were achieved with the combined usage of the central apertures and axial/lateral apertures.
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影响因子：
2.6
作者：
Chen, Ling;Tsui, Benjamin M. W.;Mok, Greta S. P.
通讯作者：
Mok, Greta S. P.
DOI：
10.1109/trpms.2018.2831208
发表时间：
2018-09-01
影响因子：
4.4
作者：
Konik, Arda;De Beenhouwer, Jan;King, Michael A.
通讯作者：
King, Michael A.
影响因子：
1.3
作者：
Min, Byung Jun;Choi, Yong;Joung, Jinhun
通讯作者：
Joung, Jinhun
影响因子：
8.3
作者：
HILL, TC;MAGISTRETTI, PL;CLOUSE, ME
通讯作者：
CLOUSE, ME
影响因子：
3.5
作者：
Kench, P. L.;Lin, J.;Meikle, S. R.
通讯作者：
Meikle, S. R.