A meta-analysis of obesity and the risk of pancreatic cancer.
A meta-analysis of obesity and the risk of pancreatic cancer.
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DOI：
10.1038/sj.bjc.6601140
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发表时间：
2003-08-04
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
吸烟和糖尿病是胰腺癌唯一确定的危险因素。最近的研究结果表明，肥胖也可能与胰腺癌风险增加有关，但一些早期的研究不太确定。我们在对已发表数据的荟萃分析中研究了这种关系。从1966年至2003年基于计算机的文献检索中确定了6项病例对照和8项队列研究，涉及6391例胰腺癌病例。根据已发表的数据，估计了每项研究中体重指数每单位增加的相对风险。在随机效应模型中，体重指数每单位增加的汇总相对风险为1.02（95% CI：1.01-1.03）。研究结果之间存在一定的异质性（P=0.1）。对于调整了吸烟的研究和没有使用代理受访者的病例对照研究，总结的相对风险估计值略高。与正常体重（22 kg m−2）的人相比，肥胖者（30 kg m−2）的体重指数每单位估计增加将转化为1.19（95% CI：1.10-1.29）的相对风险。这些结果提供的证据表明，胰腺癌的风险可能与肥胖弱相关。然而，汇总风险的幅度较小意味着不能排除混杂的可能性。
Smoking and diabetes are the only established risk factors for pancreatic cancer. Findings from recent studies suggest that obesity may also be associated with an increased risk of pancreatic cancer, but several earlier studies were less conclusive. We examined this relationship in a meta-analysis of published data. Six case–control and eight cohort studies involving 6391 cases of pancreatic cancer were identified from a computer-based literature search from 1966 to 2003. The relative risk per unit increase in body mass index was estimated for each of the studies from the published data. In a random effects model, the summary relative risk per unit increase in body mass index was 1.02 (95% CI: 1.01–1.03). There was some evidence of heterogeneity between the studies' results (P=0.1). The summary relative risk estimates were slightly higher for studies that had adjusted for smoking and for case–control studies that had not used proxy respondents. The estimated per unit increase in body mass index would translate into a relative risk of 1.19 (95% CI: 1.10–1.29) for obese people (30 kg m−2) compared to people with a normal body weight (22 kg m−2). These results provide evidence that the risk of pancreatic cancer may be weakly associated with obesity. However, the small magnitude of the summary risk means the possibility of confounding cannot be excluded.
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影响因子：
8.8
作者：
Silverman, DT;Schiffman, M;Everhart, J;Goldstein, A;Lillemoe, KD;Swanson, GM;Schwartz, AG;Brown, LM;Greenberg, RS;Schoenberg, JB;Pottern, LM;Hoover, RN;Fraumeni, JF
通讯作者：
Fraumeni, JF
影响因子：
5.4
作者：
URSIN, G;LONGNECKER, MP;GREENLAND, S
通讯作者：
GREENLAND, S
影响因子：
6.4
作者：
GHADIRIAN, P;SIMARD, A;BOYLE, P
通讯作者：
BOYLE, P
影响因子：
158.5
作者：
Calle, EE;Rodriguez, C;Thun, MJ
通讯作者：
Thun, MJ
影响因子：
3.2
作者：
Spencer, EA;Appleby, PN;Key, TJ
通讯作者：
Key, TJ