A lacZ Reporter Transgenic Mouse Line Revealing the Development of Pulmonary Artery
A lacZ Reporter Transgenic Mouse Line Revealing the Development of Pulmonary Artery
复制标题
lacZ 报告基因转基因小鼠系揭示肺动脉的发育
DOI：
10.1007/978-981-15-1185-1_9
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Yamagishi Hiroyuki
中科院分区：
文献类型：
--
作者：
Ishizaki Reina;Uchida Keiko;Shibata Akimichi;Tsuchihashi Takatoshi;Maeda Jun;Mikoshiba Katsuhiko;Yamagishi Hiroyuki
小鼠肺血管的发育主要有两种机制，即血管生成和血管生成。在胚胎9.5天，血管内皮细胞标记物Tie2驱动的LacZ在整体转基因肺中的表达显示原始肺血管系统与主动脉囊之间的连续性[1]。扫描电子显微镜对32和34体节(E10)胚胎的血管铸型和图形重建的研究表明，肺动脉(PA)的原基起源于第六咽弓动脉的近端，并沿尾部方向直线运行[2]。在E10。5.虽然传入血管尚未被定义为血管管，但它们类似于两个丛状网络，沿着气管汇合在一起。根据这些观察，“远端血管生成”被认为是肺血管形态发生的一个模型，其中PAS来自咽弓动脉并延伸到肺芽[1]。另一项研究提供了证据，支持血管生成是小鼠肺发育过程中近端和远端血管形成的机制[3]。详细
Pulmonary vasculature in mice develops through two main mechanisms, namely angiogenesis and vasculogenesis. At embryonic day (E) 9.5, vascular endothelial marker Tie2-driven LacZ expression in whole-mount transgenic lungs showed continuity between the primitive lung vasculature and the aortic sac [1]. Scanning electron microscopic study of vascular casts and graphic reconstruction in the 32-and 34-somite (E10) embryos demonstrated that the primordium of the pulmonary artery (PA) arose from the proximal portion of the sixth pharyngeal arch artery and ran straight in the caudal direction [2]. At E10. 5, though the afferent vessels were not yet defined as vascular tubes, they resembled two plexiform networks that coalesce alongside the trachea. From these observations,“distal angiogenesis” was proposed as a model for the pulmonary vascular morphogenesis where PAs arise from the pharyngeal arch artery and elongate into the lung buds [1]. Another study provided evidence to support vasculogenesis as the mechanism of both proximal and distal vessel formation during the development of murine lungs [3]. Detailed
影响因子：
11.8
作者：
Greif, Daniel M.;Kumar, Maya;Lighthouse, Janet K.;Hum, Justine;An, Andrew;Ding, Ling;Red-Horse, Kristy;Espinoza, F. Heman;Olson, Lorin;Offermanns, Stefan;Krasnow, Mark A.
通讯作者：
Krasnow, Mark A.
影响因子：
2.5
作者：
Tollet, J;Everett, AW;Sparrow, MP
通讯作者：
Sparrow, MP
影响因子：
2.7
作者：
Ishizaki-Asami, Reina;Uchida, Keiko;Yamagishi, Hiroyuki
通讯作者：
Yamagishi, Hiroyuki