Surface-Anchored Metal-Organic Framework-Cotton Material for Tunable Antibacterial Copper Delivery.
Surface-Anchored Metal-Organic Framework-Cotton Material for Tunable Antibacterial Copper Delivery.
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DOI：
10.1021/acsami.7b19455
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发表时间：
2018-05-02
影响因子：
9.5
通讯作者：
Reynolds MM
中科院分区：
文献类型：
--
作者：
Rubin HN;Neufeld BH;Reynolds MM
在本研究中，战略性地制造了一种新的铜金属有机框架（MOF）-棉材料，以利用其抗菌特性进行合成后修饰（PSM），以引入游离胺来调节材料的物理化学性质。利用天然棉花的羧甲基化的改进方法来增加用于MOF生长的成核位点的数量。随后，通过逐层浸涂工艺将MOF Cu 3（NH 2BTC）2合成为均匀的表面支撑膜。所得材料含有均匀分布在每个羧甲基化纤维周围的1 μm × 1 μm八面体MOF晶体。重要的是，M0 F配体的可接近的游离胺允许M0 F-棉表面与戊酸酐的PSM，产生23.5 ± 2.2%的改性。在生物条件下，在37 °C下浸没在复合介质中，探测材料的Cu 2+离子释放性能。实际上，PSM在前6小时内诱导材料铜通量的变化。材料继续缓慢释放Cu 2+离子超过24 h，未改性的MOF棉的通量为0.22 ± 0.003 μmol·cm−2·h−1，改性的MOF棉的通量为0.25 ± 0.004 μmol·cm−2·h−1。使用大肠杆菌通过在各种条件下测试粘附细菌和附着细菌来探索材料的抗菌活性。MOF-棉材料引起抗菌作用，在暴露24小时后产生4-log减少或更大。此外，MOF-棉材料在干燥和潮湿条件下都抑制细菌的附着。这种类型的材料将是服装、绷带和其他纺织品应用的理想材料。因此，这项工作可以优先开发均匀，可调的MOF复合纺织材料，可以杀死细菌并防止细菌附着在表面上。
In the present study, a new copper metal-organic framework (MOF)–cotton material was strategically fabricated to exploit its antibacterial properties for postsynthetic modification (PSM) to introduce a free amine to tune the physicochemical properties of the material. A modified methodology for carboxymethylation of natural cotton was utilized to enhance the number of nucleation sites for the MOF growth. Subsequently, MOF Cu3(NH2BTC)2 was synthesized into a homogenous surface-supported film via a layer-by-layer dip-coating process. The resultant materials contained uniformly distributed 1 μm × 1 μm octahedral MOF crystals around each carboxymethylated fiber. Importantly, the accessible free amine of the MOF ligand allowed for the PSM of the MOF–cotton surface with valeric anhydride, yielding 23.5 ± 2.2% modified. The Cu2+ ion-releasing performance of the materials was probed under biological conditions per submersion in complex media at 37 °C. Indeed, PSM induces a change in the copper flux of the material over the first 6 h. The materials continue to slowly release Cu2+ ions beyond 24 h tested at a flux of 0.22 ± 0.003 μmol·cm−2·h−1 with the unmodified MOF–cotton and at 0.25 ± 0.004 μmol·cm−2·h−1 with the modified MOF–cotton. The antibacterial activity of the material was explored using Escherichia coli by testing the planktonic and attached bacteria under a variety of conditions. MOF–cotton materials elicit antibacterial effects, yielding a 4-log reduction or greater, after 24 h of exposure. Additionally, the MOF–cotton materials inhibit the attachment of bacteria, under both dry and wet conditions. A material of this type would be ideal for clothing, bandages, and other textile applications. As such, this work serves as a precedence toward developing uniform, tunable MOF–composite textile materials that can kill bacteria and prevent the attachment of bacteria to the surface.
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影响因子：
4.4
作者：
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通讯作者：
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影响因子：
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通讯作者：
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影响因子：
8.4
作者：
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