Real-time functional mapping with electrocorticography in pediatric epilepsy: comparison with fMRI and ESM findings.
Real-time functional mapping with electrocorticography in pediatric epilepsy: comparison with fMRI and ESM findings.
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DOI：
10.1177/1550059413492960
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发表时间：
2014-07
影响因子：
2
通讯作者：
Lee KH
中科院分区：
文献类型：
--
作者：
Korostenskaja M;Wilson AJ;Rose DF;Brunner P;Schalk G;Leach J;Mangano FT;Fujiwara H;Rozhkov L;Harris E;Chen PC;Seo JH;Lee KH
SIGFRIED（SIGnal modeling For Real-time Identification and Event Detection）软件为准备接受切除手术的癫痫患者提供功能皮层的实时功能映射（RTFM）。目前的研究提出了第一个应用范例中使用的功能性磁共振成像（fMRI）和电皮层刺激映射（ESM）的研究共享功能性皮层映射的上下文中的RTFM。三种模式的结果进行了比较。一名患有难治性癫痫的13岁男性左撇子患者，采用功能磁共振成像（fMRI）、ESM和RTFM对语言功能皮层进行功能定位。对于RTFM，在额叶和颞叶皮层上采集数据。几个范式依次介绍：被动（听故事）和主动（图片命名和动词生成）。对于动词生成和故事处理，功能磁共振成像显示非典型的右侧语言激活颞叶感兴趣区域（ROI）和双侧额叶激活轻微的右侧。左半球ESM显示没有语言功能区。RTFM程序使用的故事处理和图片命名引起的活动在右侧和基底颞区。动词生成引起了强烈的右侧颞叶激活以及左额叶激活。RTFM结果证实了fMRI和ESM的非典型语言偏侧化。我们证明了在术前评估期间实施新RTFM刺激范例的可行性和有用性。功能磁共振成像中使用的块设计范例可能是最佳的为此目的。需要进一步开发以创建适合年龄的RTFM测试电池。
The SIGFRIED (SIGnal modeling For Real-time Identification and Event Detection) software provides real-time functional mapping (RTFM) of eloquent cortex for epilepsy patients preparing to undergo resective surgery. The current study presents the first application of paradigms used in functional magnetic resonance (fMRI) and electrical cortical stimulation mapping (ESM) studies for shared functional cortical mapping in the context of RTFM. Results from the three modalities are compared. A left-handed 13-year old male with intractable epilepsy participated in functional mapping for localization of eloquent language cortex with fMRI, ESM, and RTFM. For RTFM, data were acquired over the frontal and temporal cortex. Several paradigms were sequentially presented: passive (listening to stories) and active (picture naming and verb generation.) For verb generation and story processing, fMRI showed atypical right lateralizing language activation within temporal lobe regions of interest (ROI) and bilateral frontal activation with slight right lateralization. Left hemisphere ESM demonstrated no eloquent language areas. RTFM procedures using story processing and picture naming elicited activity in the right lateral and basal temporal regions. Verb generation elicited strong right lateral temporal lobe activation as well as left frontal lobe activation. RTFM results confirmed atypical language lateralization evident from fMRI and ESM. We demonstrated the feasibility and usefulness of a new RTFM stimulation paradigm implementation during pre-surgical evaluation. Block design paradigms used in fMRI may be optimal for this purpose. Further development is needed to create age-appropriate RTFM test batteries.
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影响因子：
5.6
作者：
Breier, JI;Castillo, EM;Papanicolaou, AC
通讯作者：
Papanicolaou, AC
影响因子：
4.8
作者：
Szaflarski, JP;Holland, SK;Byars, AW
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Byars, AW
影响因子：
4.6
作者：
Schalk, G;McFarland, DJ;Wolpaw, JR
通讯作者：
Wolpaw, JR
影响因子：
2.2
作者：
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通讯作者：
Klein, Gad
影响因子：
5.7
作者：
Schalk G;Leuthardt EC;Brunner P;Ojemann JG;Gerhardt LA;Wolpaw JR
通讯作者：
Wolpaw JR